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Titolo:
Primary angioplasty compared with thrombolysis: New issues in the era of glycoprotein IIb IIIa inhibition and intracoronary stenting
Autore:
Gibson, CM;
Indirizzi:
Allegheny Gen Hosp, Pittsburgh, PA 15212 USA Allegheny Gen Hosp Pittsburgh PA USA 15212 Hosp, Pittsburgh, PA 15212 USA
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 10, volume: 130, anno: 1999,
pagine: 841 - 847
SICI:
0003-4819(19990518)130:10<841:PACWTN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TISSUE-PLASMINOGEN-ACTIVATOR; IMMEDIATE CORONARY ANGIOPLASTY; INTRAVENOUS STREPTOKINASE; RECEPTOR BLOCKADE; TRIAL; THERAPY; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gibson, CM Allegheny Gen Hosp, 320 E North Ave, Pittsburgh, PA 15212 USA Allegheny Gen Hosp 320 E North Ave Pittsburgh PA USA 15212 USA
Citazione:
C.M. Gibson, "Primary angioplasty compared with thrombolysis: New issues in the era of glycoprotein IIb IIIa inhibition and intracoronary stenting", ANN INT MED, 130(10), 1999, pp. 841-847

Abstract

The past decade has witnessed a dramatic expansion in the scope of both mechanical and pharmacologic methods for opening occluded arteries in patients with acute myocardial infarction. Although the relative merits of conventional balloon angioplasty and thrombolysis have been evaluated, this old debate is being eclipsed by new comparisons. New device technologies, such asintracoronary stenting; more potent and more fibrin-specific thrombolytic agents; and new antithrombotic and antiplatelet agents all offer the potential for improved outcomes. But despite these recent developments, the time-dependent open artery hypothesis-which states that the achievement of early, full, and sustained reperfusion is associated with better outcomes-remains essentially unchanged. This article reviews data on the ability of six revascularization strategies-stand-alone thrombolysis, conventional percutaneous transluminal coronary angioplasty, stenting, glycoprotein IIb/IIIa inhibitors plus thrombolytic agents, glycoprotein IIb/IIIa inhibitors plus interventions, and the combination of pharmacologic and mechanical interventions-to produce early, full, and sustained reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:01:15