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Titolo:
Efficacy of Shitei-To, a traditional Chinese medicine formulation, againstconvulsions in mice
Autore:
Minami, E; Shibata, H; Nunoura, Y; Namoto, M; Fukuda, T;
Indirizzi:
Kotaro Pharmaceut Co Ltd, Cent Res Lab, Nakatsu, Osaka 5310071, Japan Kotaro Pharmaceut Co Ltd Nakatsu Osaka Japan 5310071 Osaka 5310071, Japan
Titolo Testata:
AMERICAN JOURNAL OF CHINESE MEDICINE
fascicolo: 1, volume: 27, anno: 1999,
pagine: 107 - 116
SICI:
0192-415X(1999)27:1<107:EOSATC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; HICCUPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Shibata, H Kotaro Pharmaceut Co Ltd, Cent Res Lab, Nakatsu, Osaka 5310071,Japan Kotaro Pharmaceut Co Ltd Nakatsu Osaka Japan 5310071 71, Japan
Citazione:
E. Minami et al., "Efficacy of Shitei-To, a traditional Chinese medicine formulation, againstconvulsions in mice", AM J CHIN M, 27(1), 1999, pp. 107-116

Abstract

The anticonvulsant effects of Shitei-To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had noeffect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 09:35:04