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Titolo:
Hepatocyte transplantation for the treatment of human disease
Autore:
Strom, SC; Chowdhury, JR; Fox, IJ;
Indirizzi:
Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pathol, Pittsburgh, PA 15261 USA Albert Einstein Coll Med, Dept Med, New York, NY USA Albert Einstein Coll Med New York NY USA Med, Dept Med, New York, NY USA Albert Einstein Coll Med, Dept Mol Genet, New York, NY USA Albert EinsteinColl Med New York NY USA ept Mol Genet, New York, NY USA Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, New York, NY USA Albert Einstein Coll Med New York NY USA Liver Res Ctr, New York, NY USA Univ Nebraska, Dept Surg, Omaha, NE USA Univ Nebraska Omaha NE USAUniv Nebraska, Dept Surg, Omaha, NE USA
Titolo Testata:
SEMINARS IN LIVER DISEASE
fascicolo: 1, volume: 19, anno: 1999,
pagine: 39 - 48
SICI:
0272-8087(1999)19:1<39:HTFTTO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LIVER-FAILURE; CONDITIONALLY IMMORTALIZED HEPATOCYTES; MICROCARRIER-ATTACHED HEPATOCYTES; ACUTE HEPATIC-FAILURE; LONG-TERM CORRECTION; GROWTH-FACTOR LEVELS; VIVO GENE-THERAPY; HEPATOCELLULAR TRANSPLANTATION; GUNN-RATS; CELL TRANSPLANTATION;
Keywords:
hepatocyte; transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Strom, SC Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ittsburgh, PA 15261 USA
Citazione:
S.C. Strom et al., "Hepatocyte transplantation for the treatment of human disease", SEM LIV DIS, 19(1), 1999, pp. 39-48

Abstract

A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain metabolic liver diseases. Inspecific situations where the rate of death of host hepatocytes is high, the transplanted cells can repopulate the native liver. Techniques have beenestablished for the large scale isolation, culture, and cryopreservation of human hepatocytes. Shortage of donor organs and the need for immunosuppression are two major hurdles to widespread application of this procedure, and current research in experimental animals is aimed at addressing these problems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 15:25:50