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Titolo:
THE 5-HT1A RECEPTOR ANTAGONIST P-MPPI BLOCKS RESPONSES MEDIATED BY POSTSYNAPTIC AND PRESYNAPTIC 5-HT1A RECEPTORS
Autore:
ALLEN AR; SINGH A; ZHUANG ZP; KUNG MP; KUNG HF; LUCKI I;
Indirizzi:
UNIV PENN,DEPT PSYCHIAT,3600 MARKET ST,ROOM 808 PHILADELPHIA PA 19104 UNIV PENN,DEPT PSYCHIAT PHILADELPHIA PA 19104 UNIV PENN,DEPT PHARMACOL PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1-2, volume: 57, anno: 1997,
pagine: 301 - 307
SICI:
0091-3057(1997)57:1-2<301:T5RAPB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; IN-VIVO; BEHAVIORAL-RESPONSES; RAPHE NUCLEI; SDZ 216-525; SEROTONIN; 8-OH-DPAT; BUSPIRONE; AGONISTS; DORSAL;
Keywords:
SEROTONIN; P-MPPI; 8-OH-DPAT; MICRODIALYSIS; HYPOTHERMIA; 5-HT SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Allen et al., "THE 5-HT1A RECEPTOR ANTAGONIST P-MPPI BLOCKS RESPONSES MEDIATED BY POSTSYNAPTIC AND PRESYNAPTIC 5-HT1A RECEPTORS", Pharmacology, biochemistry and behavior, 57(1-2), 1997, pp. 301-307

Abstract

The present experiments examined the ability of the novel 5-HT1A receptor antagonist to block responses mediated by postsynaptic and presynaptic 5-HT1A receptors in vivo. Pretreatment with p-MPPI reduced or blocked the effect of the 5-HT1A receptor agonist 8-OH-DPAT on two responses mediated by postsynaptic 5-HT1A receptors, reduction of body temperature and the 5-HT behavioral syndrome. Administration of p-MPPI alone did not after body temperature or produce symptoms of the 5-HT syndrome. Pretreatment with p-MPPI also blocked the ability of 8-OH-DPAT to reduce extracellular 5-HT in the striatum, a response mediated by presynaptic 5-HT1A receptors in the dorsal raphe nucleus, but did not alter striatal 5-HT when administered alone. These results indicate thatp-MPPI is an effective 5-HT1A receptor antagonist in vivo with no intrinsic activity. p-MPPI may prove to be a useful pharmacological tool for studying 5-HT1A receptors and their involvement in anxiety and affective disorders. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:13:30