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Titolo:
EFFECT OF LIPID SOLUBILITY ON THE DEVELOPMENT OF CHRONIC CROSS-TOLERANCE BETWEEN ETHANOL AND DIFFERENT ALCOHOLS AND BARBITURATES
Autore:
KHANNA JM; LE AD; KALANT H; CHAU A; SHAH G;
Indirizzi:
UNIV TORONTO,DEPT PHARMACOL,MED SCI BLDG TORONTO ON M5S 1A8 CANADA ADDICT RES FDN TORONTO ON M5S 2S1 CANADA
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1-2, volume: 57, anno: 1997,
pagine: 101 - 110
SICI:
0091-3057(1997)57:1-2<101:EOLSOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; LONG-SLEEP; SENSITIVITY; RATS;
Keywords:
TOLERANCE, CHRONIC; CROSS-TOLERANCE; ALCOHOLS; BARBITURATES; LIPID SOLUBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Khanna et al., "EFFECT OF LIPID SOLUBILITY ON THE DEVELOPMENT OF CHRONIC CROSS-TOLERANCE BETWEEN ETHANOL AND DIFFERENT ALCOHOLS AND BARBITURATES", Pharmacology, biochemistry and behavior, 57(1-2), 1997, pp. 101-110

Abstract

Tolerance to ethanol and cross-tolerance to other alcohols (n-propanol, n-butanol, t-butanol, isobutanol, t-amyl alcohol, n-amyl alcohol, and benzyl alcohol) and barbiturates (pentobarbital, secobarbital, amobarbital, thiopental, barbital and phenobarbital) that differ in lipid:water partition coefficient was examined in rats after chronic pretreatment with ethanol. Tolerance and cross-tolerance were studied with three different measures (hypothermia, tilt-plane, and rotarod). Tolerance to ethanol resulted in significant cross-tolerance to alcohols withlow lipid solubility (n-propanol and t-butanol), whereas no cross-tolerance was seen with alcohols of high lipid solubility (isobutanol, n-amyl alcohol, t-amyl alcohol and benzyl alcohol). Cross-tolerance to n-butanol (which has intermediate lipid solubility) appeared to be metabolic rather than functional. Tolerance to ethanol also resulted in significant cross-tolerance to barbital and phenobarbital, but not to pentobarbital, secobarbital, amobarbital or thiopental. These studies suggest that lipid solubility is an important factor in relation to specificity of cross-tolerance to alcohols and barbiturates. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:01:56