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Titolo:
PERSISTENT INCREASES IN BASAL CEREBRAL METABOLIC-ACTIVITY INDUCED BY MORPHINE SENSITIZATION
Autore:
KRAUS MA; PIPER JM; KORNETSKY C;
Indirizzi:
BOSTON UNIV,SCH MED,DEPT PHARMACOL,80 E CONCORD ST,L-602 BOSTON MA 02118 BOSTON UNIV,SCH MED,DEPT PHARMACOL BOSTON MA 02118 BOSTON UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02118
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1-2, volume: 57, anno: 1997,
pagine: 89 - 100
SICI:
0091-3057(1997)57:1-2<89:PIIBCM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; PALLIDUM SUBSTANTIA INNOMINATA; VENTRAL STRIATOPALLIDAL SYSTEM; MEDIODORSAL THALAMIC NUCLEUS; CONDITIONED PLACE PREFERENCE; BRAIN GLUCOSE-METABOLISM; OPIOID RECEPTOR AGONIST; FREELY MOVING RATS; BEHAVIORAL SENSITIZATION; LOCOMOTOR-ACTIVITY;
Keywords:
MORPHINE; ORAL STEREOTYPY; CONDITIONING; GLUCOSE UTILIZATION; 2-DEOXYGLUCOSE; NUCLEUS ACCUMBENS; CRAVING; LIMBIC SYSTEM; EXTRAPYRAMIDAL SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Kraus et al., "PERSISTENT INCREASES IN BASAL CEREBRAL METABOLIC-ACTIVITY INDUCED BY MORPHINE SENSITIZATION", Pharmacology, biochemistry and behavior, 57(1-2), 1997, pp. 89-100

Abstract

To characterize the underlying neuroanatomic substrate of morphine (MS) sensitization, changes in the local cerebral metabolic rate for glucose (LCMRglu) were examined in 95 brain regions of male F-344 rats using the 2-deoxy-D-[1-C-14]glucose method. The results of these experiments demonstrate that MS-induced sensitization is manifested by increases in basal metabolic activity that last for at least 6 days. Although changes in basal metabolic rate were found to be more extensive in the presence of conditioned cues, the increases in LCMRglu in nonconditioned sensitized rats indicate a basic underlying pharmacologic effectof MS sensitization on basal brain activity. Regions in which MS sensitization had a lasting pharmacologic effect include the shell of the nucleus accumbens, the prelimbic area of the prefrontal cortex, and the dorsolateral prefrontal cortex. Interestingly, the core of the nucleus accumbens and regions of the caudate were found to have an increased LCMRglu only in the presence of conditioned cues, indicating conditioned brain activity without observable changes in behavior. The previous administration of an MS-sensitizing treatment was also found to after the cerebral metabolic response to a subsequent acute MS challenge (0.5 mg/kg, subcutaneously), most notably in forebrain systems. The more widespread activation of brain structures in the basal state in thepresence of conditioned cues suggests that these MS-sensitized rats may model an altered brain state related to craving in the abstinent opiate addict. (C) 1997 Elsevier Science Inc.

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Documento generato il 24/01/20 alle ore 16:11:37