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Titolo:
CHRONIC TREATMENT WITH DEXMEDETOMIDINE DESENSITIZES ALPHA(2)-ADRENERGIC SIGNAL-TRANSDUCTION
Autore:
REID K; HAYASHI Y; HSU J; MAGUIRE PA; RABIN BC; GUO TZ; MAZE M;
Indirizzi:
VAPAHCS,ANESTHESIOL SERV,3801 MIRANDA AVE PALO ALTO CA 94304 VAPAHCS,ANESTHESIOL SERV PALO ALTO CA 94304 STANFORD UNIV,DEPT ANESTHESIA STANFORD CA 94305 MOL RES INST PALO ALTO CA 94304
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1-2, volume: 57, anno: 1997,
pagine: 63 - 71
SICI:
0091-3057(1997)57:1-2<63:CTWDDA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-RECEPTOR KINASE; DEPENDENT PROTEIN-KINASE; RAT LOCUS COERULEUS; HYPNOTIC RESPONSE; ADENYLATE-CYCLASE; PERTUSSIS TOXIN; ALPHA-2-ADRENERGIC RECEPTORS; BINDING PROTEINS; DOWN-REGULATION; ALPHA-SUBUNITS;
Keywords:
ADRENERGIC RECEPTOR; ALPHA(2) AGONIST; DEXMEDETOMIDINE; TOLERANCE; LOCUS COERULEUS; PERTUSSIS TOXIN-SENSITIVE G PROTEINS; ADENYLYL CYCLASE; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K. Reid et al., "CHRONIC TREATMENT WITH DEXMEDETOMIDINE DESENSITIZES ALPHA(2)-ADRENERGIC SIGNAL-TRANSDUCTION", Pharmacology, biochemistry and behavior, 57(1-2), 1997, pp. 63-71

Abstract

Tolerance to the hypnotic response was induced in rats by chronicallyinfusing dexmedetomidine, a novel alpha(2)-adrenergic agonist. The alpha(2)-adrenocepter affinity for dexmedtomidine and para-iodoclonidinewas significantly reduced in tolerant rats, while B-max was uncharged. The ability of pertussis toxin (PTX) to ribosylate guanine nucleotide regulatory proteins (G proteins) ex vivo was reduced in tolerant rats; the quantity of PTX-sensitive G proteins was unchanged. Forskolin-stimulated adenylyl cyclase was less sensitive to inhibition by dexmedetomidine in the tolerant rats; however, acute intraperitoneal injection of dexmedetomidine still reduced cyclic adenosine monophosphate levels in tolerant rats. Both the decrease in ribosylation and the lower alpha(2)-adrenoceptor binding affinity may reflect a decrease in the ability of the G protein to couple to the alpha(2) adrenoceptors in the loecus coeruleus of tolerant rats. In this state, the alpha(2)-adrenoceptors are less capable of transducing the effector response (inhibition of adenylyl cyclase). (C) 1997 Elsevier Science Inc.

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Documento generato il 04/04/20 alle ore 12:02:43