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Titolo:
Serotonin modulates synaptic transmission in immature rat ventrolateral medulla neurons in vitro
Autore:
Hwang, LL; Dun, NJ;
Indirizzi:
Eity,nessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson C E Tennessee State Univ Johnson City TN USA 37614 ept Pharmacol, Johnson C
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 91, anno: 1999,
pagine: 959 - 970
SICI:
0306-4522(1999)91:3<959:SMSTII>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL COMMISSURAL NEURONS; PRESYNAPTIC INHIBITION; IN-VITRO; PHARMACOLOGICAL PROPERTIES; RECEPTOR SUBTYPES; 5-HT1B RECEPTORS; BINDING-SITES; BRAIN-STEM; RESPONSES; AGONISTS;
Keywords:
excitatory postsynaptic currents; inhibitory postsynaptic current; glutamate; GABA; glycine; brainstem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dun, NJ E,Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, POB 70577 E Tennessee State Univ POB 70577 Johnson City TN USA 37614 B 70577
Citazione:
L.L. Hwang e N.J. Dun, "Serotonin modulates synaptic transmission in immature rat ventrolateral medulla neurons in vitro", NEUROSCIENC, 91(3), 1999, pp. 959-970

Abstract

Patch-clamp recordings in whole-cell configuration were made from ventrolateral medulla neurons of brainstem slices from 8-12-day-old rats. 5-Hydroxytryptamine (3-30 mu M) concentration-dependently suppressed excitatory and inhibitory postsynaptic currents evoked by focal stimulation. An augmentation of inhibitory synaptic currents by 5-hydroxytryptamine was noted in a small number of neurons. 5-Hydroxytryptamine depressed synaptic currents withor without causing a significant change in holding currents and membrane conductances; the inward or outward currents induced by exogenously applied glutamate or GABA/glycine were also not significantly changed by 5-hydroxytryptamine. In paired-pulse paradigms designed to evaluate a presynaptic site of action, 5-hydroxytryptamine suppressed synaptic currents but enhanced the paired-pulse facilitation. 5-Hydroxytryptamine reduced the frequency ofminiature excitatory postsynaptic currents without significantly affectingthe amplitude. 5-Carboxamidotryptamine, 8-hydroxy-2(di-n-propylamino)tetralin, sumatriptan and N-(3-trifluoromethylphenyl)piperazine which exhibit 5-hydroxytryptamine(1) receptor agonist activity, depressed synaptic currentswith different potencies, with 5-carboxamidotryptamine being the most potent. The non-selective 5-hydroxytryptamine(1) receptor antagonist pindolol attenuated the presynaptic effect of 5-hydroxytryptamine, whereas the 5-hydroxytryptamine(1A) antagonist pindobind-5-hydroxytryptamine(1A) and 5-hydroxytryptamine(2) receptor antagonist ketanserin were ineffective. Our results indicate that 5-hydroxytryptamine suppressed synaptic transmission in ventrolateral medulla neurons by activating presynaptic 5-hydroxytryptamine(1) receptors, probably the 5-hydroxytryptamine(1B)/5-hydroxytryptamine(1D) subtype. In addition, 5-hydroxytryptamine augmented inhibitory synaptic currents in a small number of neurons the site and mechanism of this potentiating action are not known. (C) 1999 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 16:01:14