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Titolo:
Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men
Autore:
Sacktor, NC; Lyles, RH; Skolasky, RL; Anderson, DE; McArthur, JC; McFarlane, G; Selnes, OA; Becker, JT; Cohen, B; Wesch, J; Miller, EN;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA h, Dept Epidemiol, Baltimore, MD USA Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90024 USA UnivCalif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Pittsburgh, Med Ctr, Neuropsychol Res Program, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA sychol Res Program, Pittsburgh, PA USA Northwestern Univ, Sch Med, Dept Neurol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Neurol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Neuropsychol, Chicago, IL USA Northwestern Univ Chicago IL USA Med, Dept Neuropsychol, Chicago, IL USA
Titolo Testata:
NEUROLOGY
fascicolo: 8, volume: 52, anno: 1999,
pagine: 1640 - 1647
SICI:
0028-3878(19990512)52:8<1640:CATIPS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTER AIDS COHORT; DEMENTIA COMPLEX; NEUROPSYCHOLOGICAL PERFORMANCE; ZIDOVUDINE TREATMENT; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sacktor, NC Johns Hopkins Bayview Med Ctr, Dept Neurol, 4940 Eastern Ave, Baltimore, MD Johns Hopkins Bayview Med Ctr 4940 Eastern Ave Baltimore MD USA 21224
Citazione:
N.C. Sacktor et al., "Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men", NEUROLOGY, 52(8), 1999, pp. 1640-1647

Abstract

Background: Combination antiretroviral therapy including protease inhibitors (combo +PI) is effective in suppressing systemic viral load in HIV infection, but its impact on PIN-associated cognitive impairment is unclear. Objective: To determine whether psychomotor speed, a sensitive measure of impairment in PIN dementia, improves with combo+PI compared with other antiretroviral treatments. Methods: A total of 411 HIV-seropositive (HIV+) homosexual men (with longitudinal neuropsychological testing) in the Multicenter AIDS Cohort Study and, in a separate analysis, 282 HIV+ homosexual men with psychomotor slowing at baseline were classified by treatment into four groups: antiretroviral naive (no antiretroviral medication treatment), monotherapy, combination antiretroviral therapy without protease inhibitors (combo-noPI), and combo+PI. We compared longitudinal performance on three tests of psychomotor speed: the Grooved Pegboard (GP) (nondominant and dominant hands), Trail Making Test B, and the Symbol Digit Modalities Test (SDMT). Results: Relative to antiretroviral-naive and monotherapy participants, on the GP nondominant hand test, combo+PI participants with abnormal baseline neuropsychological testing showed improved performance (difference = +0.63 standard deviation [SD],p = 0.02). For the SDMT, both combo+PI participants (difference = +0.26 SD, p = 0.03) and combo-noPI participants (difference = +0.29 SD, p = 0.01) with abnormal baseline neuropsychological testing improvedcompared with antiretroviral-naive and monotherapy groups. Conclusion: Combo+PI and combo-noPI are associated with improved psychomotor speed performance in HIV+ homosexual men with abnormal neuropsychological testing.

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Documento generato il 28/11/20 alle ore 04:44:05