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Titolo:
Differential expression of group I metabotropic glutamate receptors in ratspinal cord somatic and autonomic motoneurons: Possible implications for the pathogenesis of amyotrophic lateral sclerosis
Autore:
Anneser, JMH; Borasio, GD; Berthele, A; Zieglgansberger, W; Tolle, TR;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Dept Neurol, D-81377 Munich, Germany Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 Neurol, D-81675 Munich, Germany
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 6, anno: 1999,
pagine: 140 - 147
SICI:
0969-9961(199904)6:2<140:DEOGIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURONS; CHOLINE-ACETYLTRANSFERASE; CORTICAL CULTURES; ACID RECEPTORS; SELECTIVE LOSS; VULNERABILITY; ACTIVATION; DISEASE; RILUZOLE; NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Borasio, GD UnivMunich,, Klinikum Grosshadern, Dept Neurol, Marchioninistr15, D-81377 Univ Munich Marchioninistr 15 Munich Germany D-81377 D-81377
Citazione:
J.M.H. Anneser et al., "Differential expression of group I metabotropic glutamate receptors in ratspinal cord somatic and autonomic motoneurons: Possible implications for the pathogenesis of amyotrophic lateral sclerosis", NEUROBIOL D, 6(2), 1999, pp. 140-147

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of somatic, but not autonomic, motoneurons. The reason for this selective vulnerability is unknown. The pathogenesis of ALS is thought to involve glutamatergic excitotoxic mechanisms. While overactivation of ionotropic glutamate receptors may trigger excitotoxicity, we have previously shown that stimulation of group I metabotropic glutamate receptors (mGluRs) can exert neuroprotective effects on cultured motoneurons. Using in situ hybridization, we found a differential expression of groupI mGluRs (mGluR1 and 5) in rat spinal cord. Autonomic motoneurons from thesacral parasympathetic Onuf's nucleus and thoracic sympathetic neurons, which are spared in ALS, express high levels of mGluR5, while somatic motoneurons do not. In addition, mGluR1 mRNA is found only in smaller somatic motoneurons, which seem to be less vulnerable in ALS. Thus, differential mGluR expression might provide a possible clue to the selective vulnerability of different motoneuronal subpopulations in ALS. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:25:50