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Titolo:
Physical performance and associated electrolyte changes after haemoglobin normalization: a comparative study in haemodialysis patients
Autore:
McMahon, LP; McKenna, MJ; Sangkabutra, T; Mason, K; Sostaric, S; Skinner, SL; Burge, C; Murphy, B; Crankshaw, D;
Indirizzi:
Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3052, Australia Royal Melbourne Hosp Parkville Vic Australia 3052 le, Vic 3052, Australia Victoriantniv Technol, Ctr Rehabil Exercise & Sports Sci, Dept Human Moveme Victoria Univ Technol Melbourne Vic Australia 3000 Sci, Dept Human Moveme Univ052,bourne, Dept Pharmacol, Anaesthet Res & Educ Unit, Parkville, Vic 3 Univ Melbourne Parkville Vic Australia 3052 & Educ Unit, Parkville, Vic 3 Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 5, volume: 14, anno: 1999,
pagine: 1182 - 1187
SICI:
0931-0509(199905)14:5<1182:PPAAEC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; RECOMBINANT-HUMAN-ERYTHROPOIETIN; SKELETAL-MUSCLE; HEMODIALYSIS-PATIENTS; UREMIC RATS; EXERCISE CAPACITY; INTENSE EXERCISE; DISEASE; METABOLISM; FATIGUE;
Keywords:
epoetin; exercise; haemodialysis; normal haemoglobin; potassium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: McMahon, LP Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3052, Australia Royal Melbourne Hosp Parkville Vic Australia 3052 , Australia
Citazione:
L.P. McMahon et al., "Physical performance and associated electrolyte changes after haemoglobin normalization: a comparative study in haemodialysis patients", NEPH DIAL T, 14(5), 1999, pp. 1182-1187

Abstract

Background, To determine the effects of different haemoglobin (Hb) levels on exercise performance and associated electrolyte changes, a prospective, randomized, double-blinded crossover study was completed in 14 haemodialysis patients. Methods. Performance and changes in arterial [K+] and lactate were compared at rest and during a maximal incremental cycling exercise at a Hb concentration ([Hb]) of 10 g/dl ([Hb](10)) and 14 g/dl([Hb](14)) following an initial baseline test (Hb: 8.3 +/- 0.2 g/dl, mean +/- SEM). Ages ranged from 23to 65 years and patients were divided into younger (age 23-45 years, n = 9) and older (aged 55-65 years, n = 5) groups. Results. Peak work rate and V-02 peak were higher at [Hb](14) than at [Hb](10). 145 +/- 9 vs 134 +/- 9 W, mu +/- SEM, P < 0.01, and 1.90 +/- 0.11 vs 1.61 +/- 0.11 l/min, P < 0.01, respectively. Improvements were demonstratedin both younger and older groups at the higher target [Hb], with an improved aerobic performance evident particularly in younger patients. However, performance remained below that predicted for comparable sedentary controls. Resting plasma [K+] was raised at both [Hb](10) and [Hb](14) compared withbaseline (P < 0.01) although the change in [K+] from rest to peak exercise(Delta[K+]) was similar at each level. The Delta[K+] per unit work performed (used as a marker of K+ regulation) was, however, inversely related to the [Hb] (baseline: 80 +/- 12 mu mol/l/kJ vs [Hb](10.) 61 +/- 8, P < 0.01, vs [Hb](14.) 49 +/- 7, P < 0.05). Exercise induced a significant but similarrise in lactate concentration at both target [Hb] (P < 0.001), which remained markedly elevated for at least 10 min after exercise in both younger and older groups. Conclusions. These data demonstrate that a physiological [Hb] improves, but does not normalize, exercise performance in end-stage renal failure. Bothyounger and older patients appear to benefit similarly from the enhanced oxygen transport. Impaired K+ regulation is apparently related to [Hb] and could well contribute to the observed limitations in performance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:52:33