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Titolo:
Chronic lymphocytic leukaemia presenting with central nervous system involvement
Autore:
Poplawska-Szczyglowska, L; Walewski, J; Pienkowska-Grela, B; Rymkiewicz, G; Mioduszewska, O;
Indirizzi:
Marie Curie Sklodowska Mem Inst, Ctr Oncol, Dept Lymphoproliferat Dis, Sect Marie Curie Sklodowska Mem Inst Warsaw Poland PL-02781 liferat Dis, Sect
Titolo Testata:
MEDICAL ONCOLOGY
fascicolo: 1, volume: 16, anno: 1999,
pagine: 65 - 68
SICI:
1357-0560(199904)16:1<65:CLLPWC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOGENETIC ANALYSIS; RICHTERS SYNDROME; LEUKEMIA; MORPHOLOGY; PROGNOSIS; LYMPHOMA;
Keywords:
B-cell chronic lymphocytic leukaemia; central nervous system involvement; immunophenotype; trisomy 12; FISH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Walewski, J Marie Curie Sklodowska Mem Inst, Ctr Oncol, Dept Lymphoproliferat Dis, Sect Marie Curie Sklodowska Mem Inst Ul WK Roentgena 5 Warsaw Poland PL-02781
Citazione:
L. Poplawska-Szczyglowska et al., "Chronic lymphocytic leukaemia presenting with central nervous system involvement", MED ONCOL, 16(1), 1999, pp. 65-68

Abstract

A 68-year-old man presented with hemiparesis, lymphocytosis, and cerebral lesions on MRI, Flow cytometry of blood, bone marrow and cerebrospinal fluid showed B-CLL lymphocytes with bright CD20 expression, sIg, and absence ofCD23 antigen, Fluorescence in situ hybridisation showed trisomy 12 in 50% of analysed peripheral mononuclear cells. The patient died 6 months after the diagnosis, Rapidly progressive and fatal course of the disease was consistent with known bad prognostic significance of CD20 bright expression and trisomy 12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 15:55:05