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Titolo:
Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine threonine protein phosphatase inhibitors
Autore:
Uzunoglu, S; Uslu, R; Tobu, M; Saydam, G; Terzioglu, E; Buyukkececi, F; Omay, SB;
Indirizzi:
Ege Univ, Sch Med, Dept Hematol, TR-35100 Izmir, Turkey Ege Univ Izmir Turkey TR-35100 Med, Dept Hematol, TR-35100 Izmir, Turkey Celal Bayar Univ, Fac Sci & Arts, Dept Mol Biol, Manisa, Turkey Celal Bayar Univ Manisa Turkey ci & Arts, Dept Mol Biol, Manisa, Turkey Ege Univ, Sch Med, Dept Med Oncol, TR-35100 Izmir, Turkey Ege Univ IzmirTurkey TR-35100 d, Dept Med Oncol, TR-35100 Izmir, Turkey Ege Univ, Sch Med, Dept Immunol, TR-35100 Izmir, Turkey Ege Univ Izmir Turkey TR-35100 Med, Dept Immunol, TR-35100 Izmir, Turkey
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 5, volume: 23, anno: 1999,
pagine: 507 - 512
SICI:
0145-2126(199905)23:5<507:AOMDOM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID; GENE-EXPRESSION; PHOSPHORYLATION; PROLIFERATION; APOPTOSIS;
Keywords:
leukemia; differentiation; methylprednisolone; phosphatase inhibitors; okadaic acid; calyculin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Omay, SB Ege Univ, Sch Med, Dept Hematol, TR-35100 Izmir, Turkey Ege UnivIzmir Turkey TR-35100 Hematol, TR-35100 Izmir, Turkey
Citazione:
S. Uzunoglu et al., "Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine threonine protein phosphatase inhibitors", LEUK RES, 23(5), 1999, pp. 507-512

Abstract

To elucidate the roles of serine/threonine protein phosphatases type 1 (PP1) and type 2A (PP2A) in methylprednisolone-induced differentiation of HL60cells into granulocytes and K562 cells into monocytes, we examined the effect of serine/threonine protein phosphatase inhibitors, okadaic acid and Gal-A on the proliferation/ differentiation of HL60 and K562 cells. Okadaic acid and Gal-A augmented methylprednisolone induced granulocytic differentiation and cell death of HL60 cells and monocytic differentiation and cell death of K562 cells in different dose ranges, respectively. These data suggest an important role of PP1 and PP2A in the mechanism leading to differentiation of leukemic cells. (C) 1999 Elsevier Science Ltd. AU rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:06:37