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Titolo:
Bovine herpes virus expressing envelope protein (E2) of bovine viral diarrhea virus as a vaccine candidate
Autore:
Kweon, CH; Kang, SW; Choi, EJ; Kang, YB;
Indirizzi:
Minist Agr & Forestry, Natl Vet Res & Quarantine Serv, Anyang, South KoreaMinist Agr & Forestry Anyang South Korea tine Serv, Anyang, South Korea
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 4, volume: 61, anno: 1999,
pagine: 395 - 401
SICI:
0916-7250(199904)61:4<395:BHVEEP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPESVIRUS-1 BHV-1 RECOMBINANTS; PRV GLYCOPROTEINS GB; INSECT CELLS; HOG-CHOLERA; PSEUDORABIES; CLONING; GENE; INFECTION; SEQUENCE; DISEASE;
Keywords:
BVDV; expression of E2 protein; TK- BHV-1 recombinant; viral vector;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kweon, CH Minist Agr & Forestry, Natl Vet Res & Quarantine Serv, Anyang, South Korea Minist Agr & Forestry Anyang South Korea Anyang, South Korea
Citazione:
C.H. Kweon et al., "Bovine herpes virus expressing envelope protein (E2) of bovine viral diarrhea virus as a vaccine candidate", J VET MED S, 61(4), 1999, pp. 395-401

Abstract

The gene encoding the envelope protein (E2) of bovine viral diarrhea virus(BVDV) was expressed under the thymidine kinase (TK) promoter of Korean bovine herpesvirus 1 (BHV-1) isolate. Thymidine kinase negative (TK-) BHV-1 recombinants expressing E2 of BVDV were constructed and the expression of E2was identified by immunofluorescence and Western blotting. Compared to wild type BHV-1, the recombinant: BHV-1 had a delayed cytopathogenic effect incells. The immunogenicity of the recombinant BHV-1 was examined in guinea pigs and cattle. Although an increase in body temperature was detected for a few days, the inoculated cattle returned to normal temperature with the development of neutralizing antibodies to BVDV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:48:54