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Titolo:
Feasibility of lovastatin analysis by packed column supercritical fluid chromatography with ultraviolet detection
Autore:
Strode, JTB; Taylor, LT; Howard, AL; Ip, D;
Indirizzi:
Virginia,Polytech Inst & State Univ, Coll Arts & Sci, Dept Chem, Blacksburg Virginia Polytech Inst & State Univ Blacksburg VA USA 24061 m, Blacksburg Merck Res Labs, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486Merck Res Labs, W Point, PA 19486 USA
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 20, anno: 1999,
pagine: 137 - 143
SICI:
0731-7085(199906)20:1-2<137:FOLABP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEVINOLINIC ACID;
Keywords:
lovastatin analysis; supercritical fluid chromatography; ultraviolet detection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, LT Virginiaonolytech Inst & State Univ, Coll Arts & Sci, Dept Chem, 107 Davids Virginia Polytech Inst & State Univ 107 Davidson Hall Blacksburg VA USA 24061
Citazione:
J.T.B. Strode et al., "Feasibility of lovastatin analysis by packed column supercritical fluid chromatography with ultraviolet detection", J PHARM B, 20(1-2), 1999, pp. 137-143

Abstract

A reliable supercritical fluid chromatography (SFC) method was developed for the analysis of lovastatin, a hypocholesterolaemic drug, from MEVACOR(R). Methanol-modified carbon dioxide was shown to elute the drug, and its dehydrolovastatin and hydroxy acid lovastatin degradation products from a Hypersil(R) silica column. However, the hydroxy acid lovastatin was found to tail in this mobile phase. The phenomena was eliminated by the addition of trifluoroacetic acid [Haouck, S. Thomas, D. K. Ellison, Talanta 40 (1993) 491] to the mobile phase which permitted the drug and its two main degradationproducts to all elute from the Hypersil(R) silica column in under 6 min with symmetrical peak shape. Chromatographic limit of detection (LOD) and limit of quantification (LOQ), linear dynamic range (LDR), and injection precision were obtained in order to assess the chromatographic performance of the SFC system for the lovastatin separation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:37:34