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Titolo:
Dysembryoplastic neuroepithelial tumors: nonspecific histological forms - A study of 40 cases
Autore:
Daumas-Duport, C; Varlet, P; Bacha, S; Beuvon, F; Cervera-Pierot, P; Chodkiewicz, JP;
Indirizzi:
Hop St Anne, Dept Pathol, F-75674 Paris 14, France Hop St Anne Paris France 14 Anne, Dept Pathol, F-75674 Paris 14, France Hop St Anne, Dept Neurosurg, F-75674 Paris, France Hop St Anne Paris France F-75674 , Dept Neurosurg, F-75674 Paris, France Cochin Port Royal Univ, Dept Pathol Neurooncol, Paris, France Cochin Port Royal Univ Paris France pt Pathol Neurooncol, Paris, France
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 41, anno: 1999,
pagine: 267 - 280
SICI:
0167-594X(199902)41:3<267:DNTNHF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; CHILDHOOD BRAIN-TUMORS; INTRACTABLE EPILEPSY; MALFORMATIVE LESIONS; CORTICAL DYSPLASIA; SURGICAL PATHOLOGY; CHILDREN; SEIZURES; SURVIVAL; CLASSIFICATION;
Keywords:
brain neoplasms; child; dysembryoplastic neuroepithelial tumors; epilepsy surgery; imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Daumas-Duport, C Hop St Anne, Dept Pathol, 1 Rue Cabanis, F-75674 Paris 14, France Hop St Anne 1 Rue Cabanis Paris France 14 ris 14, France
Citazione:
C. Daumas-Duport et al., "Dysembryoplastic neuroepithelial tumors: nonspecific histological forms - A study of 40 cases", J NEURO-ONC, 41(3), 1999, pp. 267-280

Abstract

Objective. To demonstrate that DNTs include a large morphological spectrumof tumors that cannot be histologically distinguished from conventional categories of gliomas. Methods. All tumors from patients who underwent epilepsy surgery in Sainte-Anne hospital (Paris) that histologically resembled gliomas and did not conform to current histological criteria for DNTs or gangliogliomas were entered in the study. Results, According to the WHO histological classification, the 40 tumors resembled: pilocytic astrocytomas (4 cases), astrocytomas (16 cases), anaplastic astrocytoma (1 case), oligodendrogliomas (10 cases), oligo-astrocytomas (8 cases) or anaplastic oligo-astrocytomas (1 case). However foci of cortical dysplasia could be observed in 47% of the cases. Clinical presentationand imaging features were strikingly similar to that observed in typical DNTs. Although surgical removal was incomplete in 28% of the cases and none of the patients underwent chemo or radiotherapy, none of the tumors recurred (mean follow-up: 7 years). Moreover, serial preoperative imaging in 26 patients (mean follow-up: 4.5 years) demonstrated that these lesions were perfectly stable. Conclusions. Whatever the histological appearance of a glial tumor, the diagnosis of DNT must be considered when all the following criteria are associated: (1) partial seizures, with or without secondary generalization, beginning before the age 20 years, (2) no neurological deficit or stable congenital deficit, (3) cortical topography of the lesion as better demonstrated by MRI and (4) no mass effect on imaging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:47:48