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Titolo:
Two stages of increased IgA transfer during lactation in the marsupial, Trichosurus vulpecula (brushtail possum)
Autore:
Adamski, FM; Demmer, J;
Indirizzi:
Ruakura Agr Res Ctr, AgRes, Diary Sci Grp, Hamilton, New Zealand Ruakura Agr Res Ctr Hamilton New Zealand Sci Grp, Hamilton, New Zealand
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 162, anno: 1999,
pagine: 6009 - 6015
SICI:
0022-1767(19990515)162:10<6009:TSOIIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERIC IMMUNOGLOBULIN RECEPTOR; POUCH-YOUNG MARSUPIALS; CYTOPLASMIC DOMAIN; MONODELPHIS-DOMESTICA; MOLECULAR-CLONING; MAMMARY-GLAND; J-CHAIN; MILK; INTERNALIZATION; PHALANGERIDAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Adamski, FM RuakuraZealands Ctr, AgRes, Diary Sci Grp, Private Bag 3123, Hamilton, New Ruakura Agr Res Ctr Private Bag 3123 Hamilton New Zealand ew
Citazione:
F.M. Adamski e J. Demmer, "Two stages of increased IgA transfer during lactation in the marsupial, Trichosurus vulpecula (brushtail possum)", J IMMUNOL, 162(10), 1999, pp. 6009-6015

Abstract

The polymeric Ig receptor (pIgR) and J chain molecules are involved in thetransfer of IgA across the mammary gland epithelia into milk. The J chain hinds two IgA molecules to form dimeric IgA, and the pIgR transports this complex through epithelial cells. We report here the cloning of the first marsupial homologues for the pIgR and J chain from the brushtail possum, Marsupial young are born after a short gestation and are less developed than eutherian newborn. The pouch young is completely dependent on milk as its sole source of nutrition during; early lactation and this phase can be considered to be equivalent to an external gestation. Two periods of increased expression of pIgR, J chain, and IgA heavy chain mRNAs were observed in the mammary gland during lactation. The first occurs for a brief period after birth of the pouch young and is likely to reflect IgA transfer via the colostrum. The second period of increased expression, which is unique to marsupials, occurs after the early lactation period and just before young exit the pouch. We propose that this represents a second colostral-like phase at the end of the external gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:15:59