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Titolo:
Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin
Autore:
Tilbrook, AJ; de Kretser, DM; Clarke, IJ;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 siol, Clayton, Vic 3168, Australia Monash Univ, Inst Reprod & Dev, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Dev, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 161, anno: 1999,
pagine: 219 - 229
SICI:
0022-0795(199905)161:2<219:CITSEO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; MONKEY MACACA-MULATTA; LUTEINIZING-HORMONE; GONADOTROPIN-SECRETION; SERUM INHIBIN; REPRODUCTIVE DEVELOPMENT; CIRCULATING INHIBIN; TESTOSTERONE LEVELS; TESTICULAR INHIBIN; CASTRATED RAMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tilbrook, AJ Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 , Vic 3168, Australia
Citazione:
A.J. Tilbrook et al., "Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin", J ENDOCR, 161(2), 1999, pp. 219-229

Abstract

We have investigated the effectiveness of human recombinant inhibin A (hr-inhibin A) to suppress the secretion of follicle-stimulating hormone (FSH) in ram lambs from 1 to 18 months of age. Seventeen rams (nine castrated, eight intact) were used. At 1, 3, 6, 9, 12 and 18 months of age the rams weregiven an i.v. injection of either vehicle or hr-inhibin A (0.64 mu g/kg). Blood samples were taken over 24 h. Plasma concentrations of FSH were suppressed in castrated and intact rams following injection of hr-inhibin A withmaximal suppression occurring 6 h after injection. Vehicle injection had no effect. At 12 months of age the suppression in FSH was most rapid in castrated rams and was maximal in intact rams. The clearance rate of inhibin was greatest at older ages but during the period of seasonally induced testicular activity, there was a significant decrease in the inhibin clearance. The testicular weight was reduced in rams treated with hr-inhibin A, indicating the importance of FSH for testicular development during the pubertal period. There was no effect of hr-inhibin A on plasma concentrations of luteinizing hormone. We conclude that inhibin is capable of suppressing the secretion of FSH in rams from 1 month of age onwards and that the pituitary gland becomes maximally responsive to the actions of inhibin by the age of puberty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:17:35