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Titolo:
Repression of dioxin signal transduction in fibroblasts - Identification of a putative repressor associated with Arnt
Autore:
Gradin, K; Toftgard, R; Poellinger, L; Berghard, A;
Indirizzi:
Karolinskaweden, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, S Karolinska Inst Stockholm Sweden S-17177 Mol Biol, S-17177 Stockholm, S Karolinska Inst, Ctr Nutr & Toxicol, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 oxicol, S-14157 Huddinge, Sweden Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Dept Cell & Mol Biol, S-90187 Umea, Sweden
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 19, volume: 274, anno: 1999,
pagine: 13511 - 13518
SICI:
0021-9258(19990507)274:19<13511:RODSTI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING; AH-RECEPTOR; HISTONE ACETYLATION; TRANSCRIPTIONAL REPRESSION; CHROMATIN STRUCTURE; MESSENGER-RNA; GENE FAMILY; EXPRESSION; PROTEIN; RECRUITMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Gradin, K Karolinskackholm,Med Nobel Inst, Dept Cell & Mol Biol, Box 285, S-17177 Sto Karolinska Inst Box 285 Stockholm Sweden S-17177 5, S-17177 Sto
Citazione:
K. Gradin et al., "Repression of dioxin signal transduction in fibroblasts - Identification of a putative repressor associated with Arnt", J BIOL CHEM, 274(19), 1999, pp. 13511-13518

Abstract

Heterodimeric complexes of basic helix-loop-helix/PAS transcription factors are involved in regulation of diverse physiological phenomena such as circadian rhythms, reaction to low oxygen tension, and detoxification, In fibroblasts, the basic helix-loop-helix/PAS heterodimer consisting of the ligand-inducible dioxin receptor and Arnt shows DNA-binding activity, and the receptor and Arnt are able to activate transcription when fused to a heterologous DNA-binding domain. However, fibroblasts are nonresponsive to dioxin with regard to induction mediated by the DNA response element recognized by the receptor and Arnt. Here we demonstrate that Arnt is associated with a fibroblast-specific factor, forming a complex that is capable of binding thedioxin response element. This factor may function as a repressor since negative regulation of target gene induction appears to be abolished by inhibition of histone deacetylase activity by trichostatin A. Finally, the negative regulatory function of this factor appears to be restricted for dioxin signaling since Ar-nt was able to mediate, together with hypoxia-inducible factor-la, transcriptional activation in hypoxic cells. Taken together, these data suggest that fibroblast-specific inhibition of dioxin responsivenessinvolves recruitment by Arnt of a cell type- and signaling pathway-specific corepressor associated with a histone deacetylase.

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Documento generato il 21/09/20 alle ore 17:45:50