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Titolo:
L-SELECTIN IS INVOLVED IN LYMPHOCYTE MIGRATION TO SITES OF INFLAMMATION IN THE SKIN - DELAYED REJECTION OF ALLOGRAFTS IN L-SELECTIN-DEFICIENT MICE
Autore:
TANG MLK; HALE LP; STEEBER DA; TEDDER TF;
Indirizzi:
DUKE UNIV,MED CTR,DEPT IMMUNOL,BOX 3010 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT IMMUNOL DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PEDIAT ALLERGY IMMUNOL DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PATHOL DURHAM NC 27710
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 158, anno: 1997,
pagine: 5191 - 5199
SICI:
0022-1767(1997)158:11<5191:LIIILM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE ADHESION MOLECULE-1; HOMING T-CELLS; P-SELECTIN; IN-VIVO; DIFFERENTIAL REGULATION; CHEMOTACTIC FACTORS; EXPRESSION; ANTIGEN; INVIVO; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M.L.K. Tang et al., "L-SELECTIN IS INVOLVED IN LYMPHOCYTE MIGRATION TO SITES OF INFLAMMATION IN THE SKIN - DELAYED REJECTION OF ALLOGRAFTS IN L-SELECTIN-DEFICIENT MICE", The Journal of immunology, 158(11), 1997, pp. 5191-5199

Abstract

Adhesion of leukocytes to vascular endothelium is crucial for leukocyte migration into tissues. The contributions of L-selectin, P-selectin, and ICAM-1 to interactions between lymphocytes and endothelium was examined using allogeneic skin graft rejection as a model of cutaneous inflammation, L-selectin-deficient (L-selectin(-/-)) mice rejected both primary and secondary allogeneic (BALB/c) skin grafts significantly more slowly than L-selectin(+/+) littermates. Furthermore, skin graft rejection remained significantly delayed in L-selectin(-/-) mice, despite placement of grafts 7 days after i.p. immunization with allogeneiccells, when CTL responses in L-selectin(-/-) mice and L-selectin(+/+)littermates were confirmed to be equivalent. Indeed, specific CTL responses to BALB/c splenocytes were normal or elevated in L-selectin(-/-) mice following either skin grafts or immunization, However, the number of T lymphocytes within allogeneic grafts was lower in L-selectin(-/-) mice as compared with L-selectin(+/+) littermates. Therefore, delayed rejection of skin grafts by L-selectin(-/-) mice reflects impairedmigration of effector cells into the graft rather than delayed or impaired generation of a CTL response. In contrast to L-selectin(-/-) mice, P-selectin-deficient and ICAM-1-deficient mice rejected allogeneic skin grafts normally. These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:16:10