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Titolo:
Cell-density (cycle) dependent silencer of the rat insulin-like growth factor binding protein-2 (IGFBB-2) gene
Autore:
Kutoh, E; Margot, J; Schwander, J;
Indirizzi:
Kantonsspital, Zentrum Lehre & Forsch, CH-4031 Basel, Switzerland Kantonsspital Basel Switzerland CH-4031 rsch, CH-4031 Basel, Switzerland Janssen Res Fdn, Dept Pharmacol 2, B-2340 Beerse, Belgium Janssen Res FdnBeerse Belgium B-2340 harmacol 2, B-2340 Beerse, Belgium
Titolo Testata:
GROWTH FACTORS
fascicolo: 3, volume: 16, anno: 1999,
pagine: 217 - 223
SICI:
0897-7194(1999)16:3<217:C(DSOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALVEOLAR EPITHELIAL-CELLS; TRANSCRIPTION; ELEMENT; EXPRESSION; PROMOTER; HORMONE; SITES; LIVER;
Keywords:
growth factor; cell-cycle; cancer; transcription repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kutoh, E Kantonsspital, Zentrum Lehre & Forsch, CH-4031 Basel, SwitzerlandKantonsspital Basel Switzerland CH-4031 4031 Basel, Switzerland
Citazione:
E. Kutoh et al., "Cell-density (cycle) dependent silencer of the rat insulin-like growth factor binding protein-2 (IGFBB-2) gene", GROW FACTOR, 16(3), 1999, pp. 217-223

Abstract

An element,which has a negative effect on transcription has been identified in the 5'-flanking region of the rat insulin-like growth factor binding protein-2 (IGFBP-2) gene. This element was confirmed to be a silencer by truncation or by linking it to a heterologous promoter. The silencer activity disappeared in the growth-arrested BRL-3A cells at the G1/S border by high cell density where the IGFBP-2 production is highly elevated. This observation may represent a novel mechanism through which gene expression is controlled by modulation of a silencer. Taken together, these results suggest a regulatory link between cell growth and IGFBP-2 expression regulated by its silencer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:56:11