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Titolo:
Antitussive effect of K+ channel openers
Autore:
Poggioli, R; Benelli, A; Arletti, R; Cavazzuti, E; Bertolini, A;
Indirizzi:
Univ Modena, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 , Pharmacol Sect, I-41100 Modena, Italy Reggio Emilia, I-41100 Modena, Italy Reggio Emilia Modena Italy I-41100Reggio Emilia, I-41100 Modena, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 371, anno: 1999,
pagine: 39 - 42
SICI:
0014-2999(19990423)371:1<39:AEOKCO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIGS; RECEPTORS; MORPHINE; COUGH; ANTAGONIST; NEURONS; RAT;
Keywords:
K-ATP; channel opener; pinacidil; cromakalim; codeine; antitussive effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Poggioli, R Univna,dena, Dept Biomed Sci, Pharmacol Sect, Via G Campi 287,I-41100 Mode Univ Modena Via G Campi 287 Modena Italy I-41100 I-41100 Mode
Citazione:
R. Poggioli et al., "Antitussive effect of K+ channel openers", EUR J PHARM, 371(1), 1999, pp. 39-42

Abstract

The effect of the K-ATP channel openers, pinacidil and cromakalim, on coughing was studied in guinea pigs exposed to a nebulized aqueous solution of citric acid (0.50 M). Both pinacidil and cromakalim, subcutaneously administered 45 min before the test, inhibited coughing. The D-50 (95% CI) were 0.95 +/- 0.90 mg/kg for cromakalim and 3.25 +/- 0.92 mg/kg for pinacidil. Under our experimental conditions, the D-50 (95% CI) of codeine was 1.74 +/- 0.75 mg/kg. The combination of cromakalim and pinacidil with codeine produced an additive effect. An additive effect was also produced by the combination of pinacidil with the selective tachykinin NK2 receptor antagonist MEN 10,627 = [cyclo(Met-Asp-Trp-Phe-Dap-Leu)cyclo(2 beta-5 beta)]. The antitussive effect of pinacidil and cromakalim was not a consequence of a bronchodilating effect, which was absent at these dose levels under our experimental conditions. These results indicate that K-ATP channel openers have an opioid-like antitussive effect and may suggest a novel approach to the symptomatic treatment of coughing. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:10:21