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Titolo:
Modulatory effect of imetit, a histamine H-3 receptor agonist, on C-fibers, cholinergic fibers and mast cells in rabbit lungs in vitro
Autore:
Nemmar, A; Delaunois, A; Beckers, JF; Sulon, J; Bloden, S; Gustin, P;
Indirizzi:
Univ Liege, Fac Med Vet, Dept Pharmacol & Toxicol, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 armacol & Toxicol, B-4000 Liege, Belgium Univ Liege, Fac Med Vet, Dept Physiol & Reprod, B-4000 Liege, Belgium UnivLiege Liege Belgium B-4000 Physiol & Reprod, B-4000 Liege, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 371, anno: 1999,
pagine: 23 - 30
SICI:
0014-2999(19990423)371:1<23:MEOIAH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; INDUCED PULMONARY-EDEMA; GUINEA-PIG LUNGS; SUBSTANCE-P; SENSORY NERVES; RELEASE; CAPSAICIN; TACHYKININS; ACETYLCHOLINE; AIRWAYS;
Keywords:
histamine H-3 receptor; lung; (rabbit); substance P; histamine; mast cell; C-fiber; cholinergic fiber;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gustin, P Univ000ege, Fac Med Vet, Dept Pharmacol & Toxicol, Blvd Colonster B 41, B-4 Univ Liege Blvd Colonster B 41 Liege Belgium B-4000 r B 41, B-4
Citazione:
A. Nemmar et al., "Modulatory effect of imetit, a histamine H-3 receptor agonist, on C-fibers, cholinergic fibers and mast cells in rabbit lungs in vitro", EUR J PHARM, 371(1), 1999, pp. 23-30

Abstract

The pharmacological mechanisms involved in the interactions between C-fibers, cholinergic fibers and mast cells were investigated in tracheally perfused rabbit lungs by measuring the simultaneous release of substance P and histamine in lung effluents. The amounts of substance P and histamine released in lung superfusates were measured by radioimmunoassay (RIA) after administration of capsaicin and carbachol. Capsaicin (10(-4) M) induced a simultaneous increase in substance P (273 +/- 56% of baseline) and histamine (460+/- 138%) release. Similarly, carbachol (10-4 M) caused an increase in therelease of both substance P (367 +/- 111%) and histamine (1379 +/- 351%). The effect of capsaicin was prevented by pretreating the lungs with the tachykinin NK, receptor antagonist SR 140333 (10(-7) M), and atropine (10(-6) M). SR 140333 prevented the carbachol-induced release of substance P but not of histamine. Exogenous substance P induced an increase in histamine release (136 +/- 7%) which was significantly greater in lungs perfused with theneutral endopeptidase inhibitor, thiorphan (10(-5) M) (272 +/- 35%). This effect was prevented, by atropine (10(-6) M). Pretreatment of lungs with imetit (5 x 10(-8) M), a selective H-3 receptor agonist, prevented the capsaicin-induced release of both mediators. Imetit also blocked the carbachol-induced release of substance P but not of histamine. Exogenous substance P-evoked histamine release was inhibited by imetit. Therefore, it can be concluded that substance P released through the action of capsaicin can activate cholinergic fibers, leading to cholinoceptor stimulation with subsequent activation of C-fibers and mast cells. While the presence of presynaptic H-3 receptors modulating substance P-induced acetylcholine release was only surmised, the existence of modulating histamine H-3 receptors on C-fibers was confirmed. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:59:59