Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors
Autore:
NGouemo, P; Faingold, CL;
Indirizzi:
So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 1, volume: 35, anno: 1999,
pagine: 39 - 46
SICI:
0920-1211(199905)35:1<39:TPGIAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPILEPSY-PRONE RATS; MESENCEPHALIC LOCOMOTOR REGION; INFERIOR COLLICULUS PLAYS; CENTRAL NERVOUS-SYSTEM; EXCITANT AMINO-ACID; FOS MESSENGER-RNA; INDUCE C-FOS; SPINAL-CORD; INCREASED RESPONSIVENESS; SUPERIOR COLLICULUS;
Keywords:
periaqueductal grey; neuronal network; audiogenic seizures; GABA; NMDA; naloxone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Faingold, CL So Illinois Univ, Sch Med, Dept Pharmacol, POB 19629, Springfield, IL 62794 So Illinois Univ POB 19629 Springfield IL USA 62794 IL 62794
Citazione:
P. N'Gouemo e C.L. Faingold, "The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors", EPILEPSY R, 35(1), 1999, pp. 39-46

Abstract

The nuclei comprising the neuronal network for audiogenic seizures (AGS) are located primarily in the brainstem. Previous studies suggested a role for the periaqueductal grey (PAG) in the AGS network. The present study evaluated this possibility in genetically-epilepsy prone rats (GEPR-9s) by examining the effects of bilateral focal microinjection of a competitive NMDA receptor antagonist (DL-2-amino-7-phosphonoheptanoic acid (AP7), 1 and 5 nmol/side), a GABA(A) agonist (gaboxedol (THIP), 10 and 15 nmol) or an opioid peptide receptor antagonist (naloxone, 5 nmol) into PAG, based on the proposed role of these receptors in PAG neurotransmission. Blockade of NMDA receptors by AP7 (both doses) or activation of GABA(A) receptors with THIP (15 nmol/side) in the PAG suppressed AGS susceptibility. Naloxone displayed a seizure-suppressant effect that was delayed and incomplete. The seizure suppressant effect of AP7 or naloxone, unlike THIP, was observed at doses that did not produce motor quiescence. These data suggest that the PAG is a requisite nucleus in the neuronal network for AGS in GEPR-9s and that GABA(A), opioid peptide and NMDA receptors in the PAG modulate AGS propagation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:25:28