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Titolo:
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
Autore:
Barrantes, ID; Elia, AJ; Wunsch, K; De Angelis, MH; Mak, TW; Rossant, J; Conlon, RA; Gossler, A; de la Pompa, JL;
Indirizzi:
Amgen Inst, Toronto, ON M5G 2C1, Canada Amgen Inst Toronto ON Canada M5G 2C1 en Inst, Toronto, ON M5G 2C1, Canada Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada Univ Toronto Toronto ON Canada M5G 2C1 ophys, Toronto, ON M5G 2C1, Canada Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada Univ Toronto Toronto ON Canada M5G 2C1 munol, Toronto, ON M5G 2C1, Canada GSF, Inst Mammalian Genet, D-85764 Oberschleissheim, Germany GSF Oberschleissheim Germany D-85764 , D-85764 Oberschleissheim, Germany Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada Univ Toronto Toronto ON Canada Dept Mol & Med Genet, Toronto, ON, Canada Univ Toronto, Dept Obstet & Gynecol, Toronto, ON, Canada Univ Toronto Toronto ON Canada ept Obstet & Gynecol, Toronto, ON, Canada Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 9, volume: 9, anno: 1999,
pagine: 470 - 480
SICI:
0960-9822(19990506)9:9<470:IBNSAL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLIT COMPLEX GENES; EGF-LIKE REPEATS; MAMMALIAN NOTCH; NERVOUS-SYSTEM; DELTA-HOMOLOG; DROSOPHILA-MELANOGASTER; TRANSMEMBRANE PROTEIN; SIGNALING PATHWAY; TYROSINE KINASE; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: de la Pompa, JL EMBL,alyuse Biol Programme, Via Ramarini 32, I-00016 Monterotondo, Rome, It EMBL Via Ramarini 32 Monterotondo Rome Italy I-00016 e, It
Citazione:
I.D. Barrantes et al., "Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse", CURR BIOL, 9(9), 1999, pp. 470-480

Abstract

Background: The process of somitogenesis can be divided into three major events: the prepatterning of the mesoderm; the formation of boundaries between the prospective somites; and the cellular differentiation of the somites; Expression and functional studies have demonstrated the involvement of the murine Notch pathway in somitogenesis, although its precise role in this process is not yet well understood. We examined the effect of mutations in the Notch pathway elements Delta like 1 (Dll1), Notch1 and RBPJ kappa on genes expressed in the presomitic mesoderm (PSM) and have defined the spatialrelationships of Notch pathway gene expression in this region. Results: We have shown that expression of Notch pathway genes in the PSM overlaps in the region where the boundary between the posterior and anteriorhalves of two consecutive somites will form. The Dill, Notch 1 and RBPJ kappa mutations disrupt the expression of Lunatic fringe (L-fng), Jagged1, Mesp1, Mesp2 and Hes5 in the PSM. Furthermore, expression of EphA4, mCer 1 and uncx4.1, markers for the anterior-posterior subdivisions of the somites, is down-regulated to different extents in Notch pathway mutants, indicatinga global alteration of pattern in the PSM. Conclusions: We propose a model for the mechanism of somite border: formation in which the activity of Notch in the PSM is restricted by L-fng to a boundary-forming territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and anterior-posterior somite identity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:16:04