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Titolo:
Biology of presenilins as causative molecules for Alzheimer disease
Autore:
Nishimura, M; Yu, G; St George-Hyslop, PH;
Indirizzi:
Univnadaonto, Dept Med, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Ca Univ Toronto Toronto ON Canada M5S 3H2 nerat Dis, Toronto, ON M5S 3H2, Ca
Titolo Testata:
CLINICAL GENETICS
fascicolo: 4, volume: 55, anno: 1999,
pagine: 219 - 225
SICI:
0009-9163(199904)55:4<219:BOPACM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PROTEIN; C-TERMINAL FRAGMENTS; PRECURSOR PROTEIN; IN-VIVO; CAENORHABDITIS-ELEGANS; MUTANT PRESENILIN-1; MISSENSE MUTATIONS; MEMBRANE-PROTEIN; GENE; APOPTOSIS;
Keywords:
Alzheimer disease; beta-amyloid precursor protein; beta-catenin; Notch 1; presenilin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: St George-Hyslop, PH Univeensonto, Dept Med, Ctr Res Neurodegenerat Dis, Tanz Neurosci Bldg,6 Qu Univ Toronto Tanz Neurosci Bldg,6 Queens Pk CrescentW Toronto ON Canada M5S 3H2
Citazione:
M. Nishimura et al., "Biology of presenilins as causative molecules for Alzheimer disease", CLIN GENET, 55(4), 1999, pp. 219-225

Abstract

Many missense mutations in the presenilins are associated with autosomal dominant forms of familial Alzheimer disease (AD). Presenilin genes encode polytopic transmembrane proteins, which are processed by proteolytic cleavage and form high-molecular-weight complexes under physiological conditions. The presenilins have been suggested to be functionally involved in developmental morphogenesis, apoptosis signal pathways, and processing of selected proteins including beta-amyloid precursor protein. Although the underlying mechanism in which presenilin mutations lead to development of AD remains elusive, one consistent mutational effect is an overproduction of long-tailed amyloid beta-peptides. Furthermore, presenilins interact with beta-catenin to form presenilin complexes and presenilin mutations effect beta-cateninsignalling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 00:30:12