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Titolo:
Three-dimensional analysis of craniofacial form in a familiar rabbit modelof nonsyndromic coronal suture synostosis using euclidean distance matrix analysis
Autore:
Burrows, AM; Richtsmeier, JT; Mooney, MP; Smith, TD; Losken, HW; Siegel, MI;
Indirizzi:
Slippery Rock Univ, Sch Phys Therapy, Slippery Rock, PA 16057 USA SlipperyRock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA Univ Pittsburgh, Sch Dent Med, Dept Anthropol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ed, Dept Anthropol, Pittsburgh, PA USA Johns Hopkins Univ, Dept Cell Biol & Anat, Baltimore, MD USA Johns HopkinsUniv Baltimore MD USA Cell Biol & Anat, Baltimore, MD USA Johnslofacial Univ, Cleft & Craniofacial Ctr, Div Plast Reconstruct & Maxil Johns Hopkins Univ Baltimore MD USA l Ctr, Div Plast Reconstruct & Maxil Univ Pittsburgh, Sch Dent Med, Dept Plast Surg, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA d, Dept Plast Surg, Pittsburgh, PA USA Univ Pittsburgh, Sch Dent Med, Dept Orthodont, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ed, Dept Orthodont, Pittsburgh, PA USA Univ Pittsburgh, Sch Dent Med, Dept Anat & Histol, Pittsburgh, PA USA UnivPittsburgh Pittsburgh PA USA Dept Anat & Histol, Pittsburgh, PA USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA & Reconstruct Surg, Pittsburgh, PA USA Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA Childrens Hosp Pittsburgh Pittsburgh PA USA 15213 ittsburgh, PA 15213 USA Cleft Palate Craniofacial Ctr, Med Serv, Pittsburgh, PA USA Cleft Palate Craniofacial Ctr Pittsburgh PA USA Serv, Pittsburgh, PA USA
Titolo Testata:
CLEFT PALATE-CRANIOFACIAL JOURNAL
fascicolo: 3, volume: 36, anno: 1999,
pagine: 196 - 206
SICI:
1055-6656(199905)36:3<196:TAOCFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARING BIOLOGICAL SHAPES; COORDINATE-FREE APPROACH; CRANIAL VAULT; GROWTH-PATTERNS; CRANIOSYNOSTOSIS; BASE; PATHOLOGY; CALVARIA; ANATOMY; STRAIN;
Keywords:
animal model; craniosynostosis; Euclidean distance matrix analysis; growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Burrows, AM Slippery Rock Univ, Sch Phys Therapy, Suite 100 North Rd, Slippery Rock, PA Slippery Rock Univ Suite 100 North Rd Slippery Rock PA USA 16057
Citazione:
A.M. Burrows et al., "Three-dimensional analysis of craniofacial form in a familiar rabbit modelof nonsyndromic coronal suture synostosis using euclidean distance matrix analysis", CLEF PAL-CR, 36(3), 1999, pp. 196-206

Abstract

Objective: Simple craniosynostoses produce predictable morphologies of thecranial vault, with growth deficits in a direction parallel to the synostosed suture and compensatory growth at sutures that are perpendicular to andattached to the synostosed one. In coronal suture synostosis, anteroposterior growth is inhibited, with compensatory growth in a transverse direction. Information on growth patterns and influence on other craniofacial regions are not as clear. This study tested the hypotheses that (1), both juvenile and adult rabbits with familial, nonsyndromic coronal suture synostosis exhibit significant size and shape differences of the entire craniofacial region relative to normal rabbits as a result of altered growth patterns and that (2), shape differences of the calvaria will precede those of the basicranium. Design: Fifty anatomic landmarks were located on 94 New Zealand white rabbit crania, The crania were divided into a juvenile, six-week-old age category (n = 53) and an adult, 18-week-old category (n 41) in order to assess shape differences at different ages. Each age category was sorted into three groups based on growth at the coronal suture: normal sutural growth, delayed onset synostosis, and complete synostosis, Landmarks were digitized in three-dimensions, and statistical analyses on shape differences were carried out using Euclidean distance matrix analysis (EDMA). Results and conclusions: Results showed that delayed onset synostosis did not produce craniofacial morphology that was different from normal at any age. However, complete synostosis yielded predictable and global craniofacial shape differences at both ages relative to normal skulls, producing an overall shorter, wider cranium with the most markedly compensating regions ina posterosuperior position of the skull. In addition, delayed onset synostosed crania showed no shape differences in the basicranium, relative to normal crania, suggesting primacy of the calvaria in this model of coronal synostosis, However, further investigations are necessary to verify primacy ofthe calvaria in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:38:46