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Titolo:
Caspases in T-cell receptor-induced thymocyte apoptosis
Autore:
Jiang, D; Zheng, LX; Lenardo, MJ;
Indirizzi:
NIAID, Mol Dev Immune Syst Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ect, Immunol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 5, volume: 6, anno: 1999,
pagine: 402 - 411
SICI:
1350-9047(199905)6:5<402:CITRTA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; FAS-MEDIATED APOPTOSIS; INDUCED NEGATIVE SELECTION; IL-1-BETA-CONVERTING ENZYME; INHIBITS APOPTOSIS; CYSTEINE PROTEASE; SIGNALING COMPLEX; FAMILY PROTEASES; MICE DEFICIENT; ICE-LIKE;
Keywords:
apoptosis; caspase; thymic selection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lenardo, MJ NIAID,10,Roomv Immune Syst Sect, Immunol Lab, NIH, 10 Ctr Dr,MSC 1892,Bldg NIAID 10 Ctr Dr,MSC 1892,Bldg 10,Room 11D09 Bethesda MD USA 20892
Citazione:
D. Jiang et al., "Caspases in T-cell receptor-induced thymocyte apoptosis", CELL DEAT D, 6(5), 1999, pp. 402-411

Abstract

Apoptosis eliminates inappropriate or autoreactive T lymphocytes during thymic development. Intracellular mediators involved in T-cell receptor (TCR)-mediated apoptosis in developing thymocytes during negative selection are therefore of great interest. Caspases, cysteine proteases that mediate mature T-cell apoptosis, have been implicated in thymocyte cell death, but their regulation is not understood. We examined caspase activities in distinct thymocyte subpopulations that represent different stages of T-cell development. We found caspase activity in CD4(+)CD8(+) double positive (DP) thymocytes, where selection involving apoptosis occurs. Earlier and later thymocyte stages exhibited no caspase activity. Only certain caspases, such as caspase-3 and caspase-8-like proteases, but not caspase-1, are active in DP thymocytes in vivo and can be activated when DP thymocytes are induced to undergo apoptosis in vitro by TCR-crosslinking. Thus, specific caspases appear to be developmentally regulated in thymocytes.

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Documento generato il 28/09/20 alle ore 14:07:13