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Titolo:
Prognostic value of histological and biological markers in pharyngeal squamous cell carcinoma: a case-control study
Autore:
Guerry, M; Vabre, L; Talbot, M; Mamelle, G; Leridant, AM; Hill, C; Bosq, J; Luboinski, B; Janot, F;
Indirizzi:
Inst Gustave Roussy, Dept Head & Neck Surg, F-94805 Villejuif, France InstGustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Biostat, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Pathol, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 11, volume: 77, anno: 1998,
pagine: 1932 - 1936
SICI:
0007-0920(199806)77:11<1932:PVOHAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; GROWTH-FACTOR RECEPTOR; C-ERBB-2 PROTEIN; GENE-EXPRESSION; PRIMARY TUMORS; HEAD; NECK; OVEREXPRESSION; AMPLIFICATION; ONCOGENE;
Keywords:
head and neck squamous cell carcinoma; distant metastasis; case-control study; c-erb-B2/HER-2/neu expression; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Janot, F Inst,Gustave Roussy, Dept Chirurg Cervicofaciale, 39 Rue Camille Desmoulins Inst Gustave Roussy 39 Rue Camille Desmoulins Villejuif France F-94805
Citazione:
M. Guerry et al., "Prognostic value of histological and biological markers in pharyngeal squamous cell carcinoma: a case-control study", BR J CANC, 77(11), 1998, pp. 1932-1936

Abstract

Between 1980 and 1985, 914 patients with head and neck squamous cell carcinoma underwent lymph node dissection in our institution. The prognostic value of clinical factors has already been reported (Mamelle et al, 1994, Am JSurg 168: 494-498). We present here a comparison of biological characteristics of pharyngeal tumours in patients who developed distant metastasis andin patients without metastasis, matched on tumour site, node site and size, and year of diagnosis. Tumour differentiation, keratinization, vascular emboli, immunohistochemical expression of p53, c-erb-B2, Rb and bcl2 were first assessed in 31 pairs of patients. Factors of potential interest were then determined in 32 additional pairs of patients. Statistical analysis showed that the risk of distant metastasis was halved in patients with tumours expressing c-erb-B2 compared with patients with c-erb-B2-negative tumours (P = 0.05), The significance of c-erb-B2 expression and its potential value as a prognostic factor is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:32:24