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Titolo:
Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver
Autore:
Moller, PH; Ivarsson, K; Stenram, U; Radnell, M; Tranberg, KG;
Indirizzi:
Univ Lund, Dept Surg, S-22185 Lund, Sweden Univ Lund Lund Sweden S-22185Univ Lund, Dept Surg, S-22185 Lund, Sweden Univ Lund, Dept Pathol, S-22185 Lund, Sweden Univ Lund Lund Sweden S-22185 iv Lund, Dept Pathol, S-22185 Lund, Sweden
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 11, volume: 77, anno: 1998,
pagine: 1884 - 1892
SICI:
0007-0920(199806)77:11<1884:CBILTA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TUMOR-CELLS; PARTIAL-HEPATECTOMY; IN-VIVO; HEPATIC METASTASES; COLON-CARCINOMA; SURGICAL STRESS; CANCER-SURGERY; GROWTH-FACTORS; HYPERTHERMIA; ANTIGEN;
Keywords:
neoplasm; laser; thermotherapy; liver; resection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Tranberg, KG Univ Lund, Dept Surg, S-22185 Lund, Sweden Univ Lund Lund Sweden S-22185 pt Surg, S-22185 Lund, Sweden
Citazione:
P.H. Moller et al., "Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver", BR J CANC, 77(11), 1998, pp. 1884-1892

Abstract

The aim of this study was to compare interstitial laser thermotherapy withexcision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma wastransplanted (implanted if not stated otherwise) into the left lateral lobe of the rat liver, and treatment was performed 8 days later. In the main experiment, rats were treated with resection of the tumour-hearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46 degrees C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection of the tumour-bearing robe, with no difference in local control. Metastatic spread after resection of the median liver lobe was similar to that observed after sham procedures for thermotherapy or resection, suggesting that the advantage of thermotherapy was not dueto a difference in surgical trauma. Additional studies showed that laser thermotherapy reduced intraperitoneal spread when treatment was suboptimal or in a tumour inoculation model and suggested that immunological mechanismsmight be involved. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour compared with resection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:06:54