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Titolo:
Influence of anions and cations on the dipole potential of phosphatidylcholine vesicles: A basis for the Hofmeister effect
Autore:
Clarke, RJ; Lupfert, C;
Indirizzi:
Max Planck Inst Biophys, Dept Biophys Chem, D-60596 Frankfurt, Germany MaxPlanck Inst Biophys Frankfurt Germany D-60596 596 Frankfurt, Germany
Titolo Testata:
BIOPHYSICAL JOURNAL
fascicolo: 5, volume: 76, anno: 1999,
pagine: 2614 - 2624
SICI:
0006-3495(199905)76:5<2614:IOAACO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOLIPID HEAD GROUPS; FLUORESCENT STYRYL DYES; CHARGE-SHIFT PROBES; BILAYER-MEMBRANES; CONFORMATIONAL-CHANGES; LIPID-MEMBRANES; PHOSPHATIDYLSERINE BILAYERS; KIDNEY NA+,K+-ATPASE; NEURONAL-ACTIVITY; PHASE-TRANSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Clarke, RJ Univ Sydney, Sch Chem, Div Phys & Theoret Chem, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ney, NSW 2006, Australia
Citazione:
R.J. Clarke e C. Lupfert, "Influence of anions and cations on the dipole potential of phosphatidylcholine vesicles: A basis for the Hofmeister effect", BIOPHYS J, 76(5), 1999, pp. 2614-2624

Abstract

Anions and cations have long been recognized to be capable of modifying the functioning of various membrane-related physiological processes. Here, a fluorescent ratio method using the styrylpyridinium dyes, RH421 and di-8-ANEPPS, was applied to determine the effect of a range of anions and cations on the intramembrane dipole potential of dimyristoylphosphatidylcholine vesicles. It was found that certain anions cause a decrease in the dipole potential. This could be explained by binding within the membrane, in support of a hypothesis originally put forward by A. L. Hodgkin and P. Horowicz [1960, J. Physiol. (Lond.) 153:404-412.] The effectiveness of the anions in reducing the dipole potential was found to be ClO4- > SCN- > I- > NO3- > Br- >Cl- > F- > SO42-. This order could be modeled by a partitioning of ions between the membrane and the aqueous phase, which is controlled predominantlyby the Gibbs free energy of hydration. Cations were also found to be capable of reducing the dipole potential, although much less efficiently than can anions. The effects of the cations was found to be trivalent > divalent >monovalent. The cation effects were attributed to binding to a specific polar site on the surface of the membrane. The results presented provide a molecular basis for the interpretation of the Hofmeister effect of lyotropic anions on ion transport proteins.

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Documento generato il 26/09/20 alle ore 07:28:24