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Titolo:
Impairment of TNF-receptor-1 signaling but not Fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
Autore:
Bachmann, R; Eugster, HP; Frei, K; Fontana, A; Lassmann, H;
Indirizzi:
Univ Vienna, Inst Neurol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Inst Neurol, A-1090 Vienna, Austria Univ Zurich Hosp, Dept Neurosurg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Clin Immunol Sect, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 154, anno: 1999,
pagine: 1417 - 1422
SICI:
0002-9440(199905)154:5<1417:IOTSBN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LISTERIA-MONOCYTOGENES; NERVOUS-SYSTEM; DEATH; DEFICIENT; INFLAMMATION; PROTEIN; LIGAND; EXPRESSION; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lassmann, H Univ Vienna, Inst Neurol, Schwarzspanierstr 17, A-1090 Vienna,Austria Univ Vienna Schwarzspanierstr 17 Vienna Austria A-1090 ustria
Citazione:
R. Bachmann et al., "Impairment of TNF-receptor-1 signaling but not Fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice", AM J PATH, 154(5), 1999, pp. 1417-1422

Abstract

T-cell apoptosis in inflammatory demyelinating lesions of chronic myelin oligodendrocyte glycoprotein peptide(35-55) induced autoimmune encephalomyelitis was studied in several different gene knockout mice as well as their wild-type counterparts. The gene deletions included tumor necrosis factor (TNF) alpha, lymphotoxin, TNF receptor 1 or 2, Fas-L, inducible nitric oxide synthase, perforin, and interleukin1 beta-converting enzyme. Impairment of the TNF receptor 1 pathway led to a 50% reduction of T-cell apoptosis in the central nervous system lesions, whereas the other genetic deletions showed no significant effect. Our study thus identified the TNF receptor 1 signaling pathway as one mechanism responsible for the removal of T lymphocytes from inflammatory demyelinating lesions of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:21:17