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Titolo:
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Autore:
Harris, TB; Ferrucci, L; Tracy, RP; Corti, MC; Wacholder, S; Ettinger, WH; Heimovitz, H; Cohen, HJ; Wallace, R;
Indirizzi:
NIA, Epidemiol Demog & Biometry Program, Bethesda, MD 20892 USA NIA Bethesda MD USA 20892 emog & Biometry Program, Bethesda, MD 20892 USA Natl REs Inst INRCA, Florence, Italy Natl REs Inst INRCA Florence ItalyNatl REs Inst INRCA, Florence, Italy Univ Vermont, Burlington, VT USA Univ Vermont Burlington VT USAUniv Vermont, Burlington, VT USA Univ Padua, Padua, Italy Univ Padua Padua ItalyUniv Padua, Padua, Italy NCI, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Bethesda, MD 20892 USA Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA ray Sch Med, Winston Salem, NC USA Sytel, Bethesda, MD USA Sytel Bethesda MD USASytel, Bethesda, MD USA Duke Univ, Sch Med, Durham, NC USA Duke Univ Durham NC USADuke Univ, Sch Med, Durham, NC USA Univ Iowa, Coll Med, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Coll Med, Iowa City, IA USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 5, volume: 106, anno: 1999,
pagine: 506 - 512
SICI:
0002-9343(199905)106:5<506:AOEIAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; SERUM AMYLOID-A; CARDIOVASCULAR-DISEASE; UNSTABLE ANGINA; RISK-FACTORS; PLASMA IL-6; HEALTHY-MEN; INFLAMMATION; METHODOLOGY; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, TB NIA,onsinemiol Demog & Biometry Program, Gateway Bldg,Room 3C-309,7201 Wisc NIA Gateway Bldg,Room 3C-309,7201 Wisconsin Ave Bethesda MD USA 20892
Citazione:
T.B. Harris et al., "Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly", AM J MED, 106(5), 1999, pp. 506-512

Abstract

PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people. SUBJECTS AND METHODS: A sample of 1,293 healthy, nondisabled participants in the Iowa 65+ Rural Health Study was followed prospectively for a mean of4.6 years. Plasma interleukin-6 and C-reactive protein levels were measured in specimens obtained from 1987 to 1989. RESULTS: Higher interleukin-6 levels were associated with a twofold greater risk of death [relative risk (RR) for the highest quartile (greater than or equal to 3.19 pg/mL) compared with the lowest quartile of 1.9 [95% confidence interval, CI, 1.2 to 3.11]. Higher C-reactive protein levels (greaterthan or equal to 2.78 mg/L) were also associated with increased risk (RR =1.6; CI, 1.0 to 2.6). Subjects with elevation of both interleukin-6 and C-reactive protein levels were 2.6 times more likely (CI, 1.6 to 4.3) to die during follow-up than those with low levels of both measurements. Similar results were found for cardiovascular and noncardiovascular causes of death,as well as when subjects were stratified by sex, smoking status, and priorcardiovascular disease, and for both early (<2.3 years) and later follow-up. Results were independent of age, sex, body mass index, and history of smoking, diabetes, and cardiovascular disease, as well as known indicators ofinflammation including fibrinogen and albumin levels and white blood cell count. CONCLUSIONS: Higher circulating levels of interleukin-6 and C-reactive protein were associated with mortality in this population-based sample of healthy older persons. These measures may be useful for identification of high-risk subgroups for anti-inflammatory interventions. (C) 1999 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:29:12