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Titolo:
Resistance to friend leukemia virus in transgenic mice expressing the native FV-4 gene
Autore:
Jackson, MK; Mitchell, EA; Winslow, SG; Okelberry, KM; Sidwell, RW; Morrey, JD;
Indirizzi:
Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA Utah StateUniv Logan UT USA 84322 m Dairy & Vet Sci, Logan, UT 84322 USA
Titolo Testata:
ACTA VIROLOGICA
fascicolo: 1, volume: 43, anno: 1999,
pagine: 19 - 23
SICI:
0001-723X(199902)43:1<19:RTFLVI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVELOPE GENE; INTERFERENCE; INFECTION; PRODUCT; SHEEP; RAT;
Keywords:
Fv-4; transgenic mice; retroviral envelope gene; viral interference; disease resistance; Friend murine leukemia virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, MK Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 t Sci, Logan, UT 84322 USA
Citazione:
M.K. Jackson et al., "Resistance to friend leukemia virus in transgenic mice expressing the native FV-4 gene", ACT VIROLOG, 43(1), 1999, pp. 19-23

Abstract

Fv-4 is a truncated ecotropic retrovirus gene that codes for an envelope protein under control of a cellular promoter. It confers resistance to ecotropic murine leukemia viruses. Transgenic mice were derived using the nativeFv-4 gene as the construct for microinjection. Two founder mice were derived. In both founder lines, there was no detectable expression of the transgene or resistance to Friend murine leukemia virus (FrMLV) in hemizygotes. In one line, the resistance was observed in homozygotes with Fv-4 RNA formation in the thymus but not in the spleen or in other tissues. Tn the other founder line, a homozygous male was identified. Double integrants, derived from breeding this homozygous male to homozygous females from the other founder line, were also resistant. These results indicate that the native gene confers the resistance in homozygous transgenic mice or double integrants derived from different founders but not hemizygotes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:47:25