Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immunogenicity and protective efficacy of a gE, gG and US2 gene-deleted bovine herpesvirus-1 (BHV-1) vaccine
Autore:
Belknap, EB; Walters, LM; Kelling, C; Ayers, VK; Norris, J; McMillen, J; Hayhow, C; Cochran, M; Reddy, DN; Wright, J; Collins, JK;
Indirizzi:
Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol, Ft Collins, Colorado State Univ Ft Collins CO USA 80523 , Dept Microbiol, Ft Collins, Univ,Nebraska, Inst Agr & Nat Resources, Div Agr Res, Dept Vet & Biomed Sci Univ Nebraska Lincoln NE USA 68583 es, Div Agr Res, Dept Vet & Biomed Sci Syntro Corp, Lenexa, KS 66219 USA Syntro Corp Lenexa KS USA 66219Syntro Corp, Lenexa, KS 66219 USA Hoechst Roussel Vet, Warren, NJ 07059 USA Hoechst Roussel Vet Warren NJ USA 07059 Roussel Vet, Warren, NJ 07059 USA Syntro Schering Plough Anim Hlth, San Diego, CA 92121 USA Syntro Schering Plough Anim Hlth San Diego CA USA 92121 ego, CA 92121 USA Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA Auburn Univ Auburn AL USA 36849 Med, Dept Pathobiol, Auburn, AL 36849 USA ColoradoCOtate Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ft Collins,Colorado State Univ Ft Collins CO USA 80523 i, Dept Clin Sci, Ft Collins,
Titolo Testata:
VACCINE
fascicolo: 18, volume: 17, anno: 1999,
pagine: 2297 - 2305
SICI:
0264-410X(19990504)17:18<2297:IAPEOA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; E-NEGATIVE STRAIN; CATTLE; TYPE-1; RHINOTRACHEITIS; IMMUNIZATION; IMMUNITY; VECTOR; DIFFERENTIATION; GLYCOPROTEINS;
Keywords:
bovine; herpesvirus; gene-deleted vaccine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Belknap, EB Auburn Univ, Coll Vet Med, Dept Large Anim Surg & Med, Auburn,AL 36849 USA Auburn Univ Auburn AL USA 36849 g & Med, Auburn, AL 36849 USA
Citazione:
E.B. Belknap et al., "Immunogenicity and protective efficacy of a gE, gG and US2 gene-deleted bovine herpesvirus-1 (BHV-1) vaccine", VACCINE, 17(18), 1999, pp. 2297-2305

Abstract

The efficacy and safety of a gene-deleted bovine herpesvirus-l (BHV-1) vaccine was determined in a bovine herpesvirus challenge trial in calves, Three different doses of the vaccine were administered intramuscularly at 10(5), 10(6) and 10(7) PFU/ml and compared to a commercial vaccine and non vaccinated control calves. Challenge was performed by intranasal aerosolization with the Cooper strain of BHV-1 (3 x 10(4) PFU/ml). The non-vaccinated calves shed significantly (P < 0.05) more virus than all other groups on days 4, 8 and 10 post challenge. By day 14 post challenge, antibody titers for BHV-1 of calves vaccinated with 107 PFU/ml were significantly (P < 0.05) higher than the commercial or non-vaccinated calves. Clinical scores of non-vaccinated calves were significantly (P < 0.05) higher than all other groups on days 4-14 post challenge. With both radioimmunoprecipitation and competitive enzyme-linked immunosorbent assays (C-ELISA), calves in the gene-deleted vaccine groups mounted comparable specific responses against gB, gC and go post vaccination as calves in the commercial vaccine group, but in a dosedependent manner. These data suggest that the gene-deleted BHV-1 vaccine tested may be used as an effective vaccine in controlling BHV-1 infections. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:29:04