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Titolo:
Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants
Autore:
Sohn, YM; Park, MS; Rho, HO; Chandler, LJ; Shope, RE; Tsai, TF;
Indirizzi:
Natl Ctr Infect Dis, CDC, Div Vector Borne Infect Dis, Ft Collins, CO 80522 Natl Ctr Infect Dis Ft Collins CO USA 80522 ect Dis, Ft Collins, CO 80522 Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Pathol, Galveston, TX 77555 USA Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea Yonsei Univ SeoulSouth Korea Coll Med, Dept Pediat, Seoul, South Korea
Titolo Testata:
VACCINE
fascicolo: 18, volume: 17, anno: 1999,
pagine: 2259 - 2264
SICI:
0264-410X(19990504)17:18<2259:PABIRT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAFETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, TF Natlampus,nfect Dis, CDC, Div Vector Borne Infect Dis, POB 2081,Foothills C Natl Ctr Infect Dis POB 2081,Foothills Campus Ft Collins CO USA 80522
Citazione:
Y.M. Sohn et al., "Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants", VACCINE, 17(18), 1999, pp. 2259-2264

Abstract

Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since1988 and recently, licensure of the vaccine in Korea has been sought. In the first clinical evaluation of the vaccine outside of China, we monitored side effects in 84 children and evaluated antibody responses to a single dose given as primary JE vaccination in 68 children, 1-3 years old (mean age 27 months). No significant adverse events were noted. Neutralizing antibodies (geometric mean titer [GMT] of 188) were produced in 96% of the 68 subjects, In 10 other children who previously had been immunized with two or three doses of inactivated JE vaccine, the booster administration of SA14-14-2vaccine produced an anamnestic response in all. with a GMT of 3378. In a comparison group of 25 children previously immunized with two doses of inactivated vaccine, neutralizing antibody titers were detected in 16 (64%), Viral specific IgM was detected in nine primary vaccinees (13%) but in others,IgM may have declined to undetectable levels in the four week postimmunization sample. Live attenuated SA14-13-2 JE vaccine is a promising alternative to the only commercially available JE vaccine for national childhood immunization programs in Asia. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:10:51