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Titolo:
Paraneoplastic opsoclonus-myoclonus syndrome revealing T-cell lymphoma
Autore:
Ducrocq, X; Petit, J; Taillandier, L; Dorvaux, V; Anxionnat, R; Plenat, F; Vespignani, H;
Indirizzi:
Hop Cent, Serv Neurol, F-54035 Nancy, France Hop Cent Nancy France F-54035 p Cent, Serv Neurol, F-54035 Nancy, France Hop Cent, Serv Neuroradiol, F-54035 Nancy, France Hop Cent Nancy France F-54035 t, Serv Neuroradiol, F-54035 Nancy, France HopeBrabois, Serv Hematol, Anat Pathol Lab, F-54500 Vandoeuvre Nancy, Franc Hop Brabois Vandoeuvre Nancy France F-54500 4500 Vandoeuvre Nancy, Franc
Titolo Testata:
PRESSE MEDICALE
fascicolo: 7, volume: 28, anno: 1999,
pagine: 330 - 333
SICI:
0755-4982(19990220)28:7<330:POSRTL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
FRE
Soggetto:
PARA-NEOPLASTIC OPSOCLONUS; ANTI-RI; CARCINOMA; ANTIBODIES; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ducrocq, X Hop Cent, Serv Neurol, CO34, F-54035 Nancy, France Hop Cent CO34 Nancy France F-54035 CO34, F-54035 Nancy, France
Citazione:
X. Ducrocq et al., "Paraneoplastic opsoclonus-myoclonus syndrome revealing T-cell lymphoma", PRESSE MED, 28(7), 1999, pp. 330-333

Abstract

BACKGROUND: Nonrhythmic involuntary ocular oscillations and axial and segmentary myoclonia are associated in the opsoclonus-myoclonus syndrome. In adults, a paraneoplastic origin is generally found. We report the first of opsoclonus-myoclonus associated with non-Hodgkin's lymphoma. CASE REPORT: A 66-year-old woman rapidly developed a typical opsoclonus-myoclonus syndrome within a few hours, presenting vertigo, cerebellous ataxia, multidirectional involuntary ocular movements and nonrhythmic axial and segmentary myoclonia. Brain computed tomography and magnetic resonance imaging demonstrated discrete diffuse anomalies of the white substance predominating in the pens. The cerebrospinal fluid showed discrete lymphocytosis. Antineuron antibodies were negative. No cause could be identified until the development 11 months later of pleomorphic T-cell mediastino-cervical lymphoma. The patient responded moderately to a CHOP regimen which had no effect on the opsoclonus-myoclonus syndrome. Death occurred after a 16-month course due to pulmonary complications. DISCUSSION: Neuroblastoma and infectious causes predominate in opsoclonus-myoclonus syndromes observed in children; in adults, the predominant cause is cancer. Antineuron, anti-Ri and anti-Hu antibodies can be evidenced in some cases, arguing in favor of a paraneoplastic mechanism. Recent reports have evidenced MRI anomalies in the pens and the cerebellum, anatomically well correlated with the opsoclonus-myoclonus syndrome. Besides small-cell bronchogenic anaplastic cancer, the possibility of cancer of the breast and uterus, and both non-Hodgkin and Hodgkin lymphoma should be explored, knowing that cancer develops several months after the opsoclonus-myoclonus syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:37:14