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Titolo:
Reduced femoral geometry but normal biomechanics in the dorsomedial hypothalamic nucleus-lesioned rat
Autore:
Kidd, RJ; Ziv, I; Bernardis, LL;
Indirizzi:
SUNY Buffalo, Dept Mech Engn, VA Western New York Healthcare Syst, Buffalo, SUNY Buffalo Buffalo NY USA 14214 tern New York Healthcare Syst, Buffalo, SUNYfalo,alo, Dept Orthopaed Surg, VA Western New York Healthcare Syst, Buf SUNY Buffalo Buffalo NY USA 14214 A Western New York Healthcare Syst, Buf SUNY214ffalo, Dept Med, VA Western New York Healthcare Syst, Buffalo, NY 14 SUNY Buffalo Buffalo NY USA 14214 ew York Healthcare Syst, Buffalo, NY 14 SUNYlo,ffalo, Dept Phys Therapy, VA Western New York Healthcare Syst, Buffa SUNY Buffalo Buffalo NY USA 14214 Western New York Healthcare Syst, Buffa SUNY,Buffalo, Dept Exercise & Nutr Sci, VA Western New York Healthcare Syst SUNY Buffalo Buffalo NY USA 14214 ci, VA Western New York Healthcare Syst SUNYYBuffalo, Dept Med Res, VA Western New York Healthcare Syst, Buffalo, N SUNY Buffalo Buffalo NY USA 14214 rn New York Healthcare Syst, Buffalo, N
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 2, volume: 66, anno: 1999,
pagine: 371 - 374
SICI:
0031-9384(199904)66:2<371:RFGBNB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-RETARDED RATS; ORGANISMIC SET POINT; CATCH-UP GROWTH; HYPOPHYSECTOMIZED RATS; FACTOR-I; INSULIN; HORMONE; SECRETION;
Keywords:
dorsomedial hypothalamic nucleus; rat; bone; growth; geometry; biomechanics; body composition; organismic set point;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ziv, I SUNYeruffalo, Dept Mech Engn, VA Western New York Healthcare Syst, 162 Farb SUNY Buffalo 162 Farber Hall,3435 Main St Buffalo NY USA 14214 Farb
Citazione:
R.J. Kidd et al., "Reduced femoral geometry but normal biomechanics in the dorsomedial hypothalamic nucleus-lesioned rat", PHYSL BEHAV, 66(2), 1999, pp. 371-374

Abstract

Bone geometry, structure, and biomechanical properties were investigated in a model of growth retardation, the dorsomedial hypothalamic nucleus-lesioned (DMNL) weanling rat. Male; weanling Sprague-Dawley rats received bilateral electrolytic lesions in the dorsomedial hypothalamic nucleus (DMN) at age 27 days. Sham-operated rats served as controls. All rats were maintainedpostoperatively for 40 days. Upon sacrifice, DMNL rats weighed less (p < 0.01), were shorter (p < 0.01), and ate less (p < 0.01) when compared to controls, but their body composition was normal. The femora in DMNL were shorter (p < 0.01), had a smaller outer anteroposterior (AP) diameter (p < 0.04), polar moment of the area (p < 0.02), and maximal (p < 0.02) and minimal (p < 0.03) principal moment of the area when compared with sham-operated rats. Notably, mean torque at failure, torsional energy, stiffness, and maximal stress did not demonstrate statistically significant differences between the two groups. These data clearly show that despite the reduced size and bone growth, DMNL rats responded normally to the mechanical challenges applied to test bone biomechanical properties. The data, therefore, add to previous evidence and strengthen the hypothesis that DMNL rats are governed by an "organismic" set point. (C) 1999 Elsevier Science Inc.

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Documento generato il 25/09/20 alle ore 00:42:25