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Titolo:
Bacterial population genetics, evolution and epidemiology
Autore:
Spratt, BG; Maiden, MCJ;
Indirizzi:
Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 Univ Oxford Oxford England OX1 3PS Ctr Epidemiol Infect Dis, Oxford OX1
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1384, volume: 354, anno: 1999,
pagine: 701 - 710
SICI:
0962-8436(19990429)354:1384<701:BPGEAE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; NEISSERIA-MENINGITIDIS; INTERSPECIES RECOMBINATION; NATURAL-POPULATIONS; HELICOBACTER-PYLORI; SALMONELLA; SPREAD; CLONES; GENES; POLYMORPHISM;
Keywords:
population structure; horizontal gene transfer; linkage disequilibrium; non-clonal; nucleotide sequencing; phylogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Spratt, BG Univ,Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, S Parks Rd Univ Oxford S Parks Rd Oxford England OX1 3PS Dis, S Parks Rd
Citazione:
B.G. Spratt e M.C.J. Maiden, "Bacterial population genetics, evolution and epidemiology", PHI T ROY B, 354(1384), 1999, pp. 701-710

Abstract

Asexual bacterial populations inevitably consist of an assemblage of distinct clonal lineages. However, bacterial populations are not entirely asexual since recombinational exchanges occur, mobilizing small genome segments among lineages and species. The relative contribution of recombination, as opposed to de novo mutation, in the generation of new bacterial genotypes varies among bacterial populations and, as this contribution increases, the clonality of a given population decreases. In consequence, a spectrum of possible population structures exists, with few bacterial species occupying the extremes of highly clonal and completely non-clonal, most containing bothclonal and non-clonal elements. The analysis of collections of bacterial isolates, which accurately represent the natural population, by nucleotide sequence determination of multiple housekeeping loci provides data that can be used both to investigate the population structure of bacterial pathogensand for the molecular characterization of bacterial isolates. Understanding the population structure of a given pathogen is important since it impacts on the questions that can be addressed by, and the methods and samples required for, effective molecular epidemiological studies.

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Documento generato il 05/04/20 alle ore 06:48:02