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Titolo:
The effects of intravenous naltrindole and naltrindole 5 '-isothiocyanate on sufentanil-induced respiratory depression and antinociception in rats
Autore:
Verborgh, C; Meert, TF;
Indirizzi:
Freegiumv Brussels, Akad Ziekenhuis, Dept Anesthesiol, B-1090 Brussels, Bel Free Univ Brussels Brussels Belgium B-1090 thesiol, B-1090 Brussels, Bel
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 63, anno: 1999,
pagine: 175 - 183
SICI:
0091-3057(199905)63:1<175:TEOINA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-OPIOID RECEPTORS; MU-MEDIATED ANTINOCICEPTION; OPIATE RECEPTORS; DIFFERENTIAL ANTAGONISM; PHYSICAL-DEPENDENCE; PERIAQUEDUCTAL GRAY; CROSS-TOLERANCE; RHESUS-MONKEYS; SPINAL-CORD; MORPHINE;
Keywords:
sufentanil; naltrindole; naltrinole 5 '-isothiocyanate; antinociception; respiratory depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Meert, TF Janssen Res Fdn, Dept Neuropsychofarmacol, Turnhoutseweg 30, B-2340 Beerse, Janssen Res Fdn Turnhoutseweg 30 Beerse Belgium B-2340 Beerse,
Citazione:
C. Verborgh e T.F. Meert, "The effects of intravenous naltrindole and naltrindole 5 '-isothiocyanate on sufentanil-induced respiratory depression and antinociception in rats", PHARM BIO B, 63(1), 1999, pp. 175-183

Abstract

Although the interactions between the mu- and the delta-opiate receptor subtypes are well documented with regard to supraspinal analgesia, less is known about the mutual interactions on respiratory depression. To clarify thefunctional interactions between both opiate receptor subtypes with regard to antinociception and respiratory depression, male Wistar rats were intravenously injected with 2.5 mu g/kg of the mu-opiate agonist sufentanil and subsequently intravenously challenged with the delta antagonist naltrindole (NTI) or naltrindole 5'-isothiocyanate (5'-NTII), a delta-2 antagonist. Antinociception was measured by means of the tail-flick latency, and respiratory depression was evaluated by means of analysis of PaCO2, PaO2, and oxygensaturation. To quantify the antagonistic properties of Nn and 5'-NTII, mean areas under the curve were calculated for groups treated with sufentanil,control vehicle, and sufentanil plus a dose of the antagonists. NTT, but not 5'-NTII, antagonized the sufentanil-induced antinociception at 10 mg/kg Nn. Below this dose the effects were inconsistent. The sufentanil-induced hypercapnia and hypoxia were diminished with 10 mg/kg NTI or 5'-NTII. These data indicate that NTI antagonizes the sufentanil-induced antinociception and respiratory depression in rats. A dissociation between the antinociception and respiratory depression following intravenous sufentanil could be obtained with 10 mg/kg 5'-NTII pointing to different regulatory effects of opiate delta receptor subtypes on mu-opiate agonist-induced behavioral effects. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:27:49