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Titolo:
Modulatory effects of ascorbate, alone or with haloperidol, on a lever-release conditioned avoidance response task
Autore:
Gulley, JM; Rebec, GV;
Indirizzi:
Indiana Univ, Dept Psychol, Program Neural Sci, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 ural Sci, Bloomington, IN 47405 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 63, anno: 1999,
pagine: 125 - 129
SICI:
0091-3057(199905)63:1<125:MEOAAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR; ANTIPSYCHOTIC-DRUGS; BEHAVIORAL-RESPONSE; STRIATAL NEURONS; NMDA-RECEPTOR; D-AMPHETAMINE; RAT-BRAIN; ACID; IONTOPHORESIS; ANTAGONISTS;
Keywords:
ascorbate; conditioned avoidance response; dopamine; glutamate; haloperidol; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Rebec, GV Indiana Univ, Dept Psychol, Program Neural Sci, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 Bloomington, IN 47405 USA
Citazione:
J.M. Gulley e G.V. Rebec, "Modulatory effects of ascorbate, alone or with haloperidol, on a lever-release conditioned avoidance response task", PHARM BIO B, 63(1), 1999, pp. 125-129

Abstract

Pretreatment with ascorbate, a modulator of dopamine transmission in the striatum. enhances the ability of haloperidol, a dopamine antagonist, to induce catalepsy and block the motor-activating effects of amphetamine. The present study extended this line of work to a lever-release version of the conditioned avoidance response (CAR) task, which is highly sensitive to changes in striatal dopamine. Adult male rats were trained to avoid footshock byreleasing a lever within 500 ms of tone onset. Ascorbate (100 and 1000 mg/kg, IF) or vehicle was tested either alone or in conjunction with haloperidol(0.01 and 0.05 mg/kg, SC). Compared to vehicle pretreatment, 1000 mg/kg ascorbate alone or in combination with haloperidol impaired CAR performance by increasing avoidance latency. Latency to escape footshock was not impaired, ruling out a generalized motor deficit. In contrast, 100 mg/kg ascorbate alone or in combination with haloperidol had no consistent efects on CAR performance, even at a haloperidol dose (0.005 mg/kg, SC) known to potentiate dopamine transmission by preferentially blocking autoreceptors. Collectively, these results support an antidopaminergic action of ascorbate on striatal function, but suggest that this effect requires relatively high systemic doses. (C) 1999 Elsevier Science Inc.

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Documento generato il 18/01/20 alle ore 11:19:04