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Titolo:
Phagocyte-induced lipid peroxidation of lung surfactant
Autore:
Bouhafs, RKL; Jarstrand, C;
Indirizzi:
HuddingePathol Karolinska Inst, Div Clin Bacteriol, Dept Immunol MicrobiolHuddinge Hosp Huddinge Sweden S-14186 Bacteriol, Dept Immunol Microbiol
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 5, volume: 27, anno: 1999,
pagine: 322 - 327
SICI:
8755-6863(199905)27:5<322:PLPOLS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; FREE FATTY-ACIDS; PULMONARY SURFACTANT; PREMATURE-INFANTS; CONTROLLED TRIAL; CLINICAL-TRIAL; DOUBLE-BLIND; POLYMORPHONUCLEAR LEUKOCYTES; EXOGENOUS SURFACTANT;
Keywords:
surfactant; free radicals; neutrophils; antioxidants; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bouhafs, RKL HuddingePathol Karolinska Inst, Div Clin Bacteriol, Dept Immunol Microbiol Huddinge Hosp Huddinge Sweden S-14186 ept Immunol Microbiol
Citazione:
R.K.L. Bouhafs e C. Jarstrand, "Phagocyte-induced lipid peroxidation of lung surfactant", PEDIAT PULM, 27(5), 1999, pp. 322-327

Abstract

Surfactant therapy is given routinely to premature newborns with respiratory failure. However, alterations in surfactants have been shown to be a significant factor in some forms of respiratory failure in newborns in animal models of lung injury. To investigate whether antioxidant supplementation might help to protect exogenous surfactant from damage by oxygen free radicals, we examined the influence of vitamin E in combination with surfactant on superoxide production as estimated by the nitroblue tetrazolium reductiontest, and measured surfactant peroxidation with a new colorimetric method with or without addition of superoxide dismutase (SOD) or vitamin E. Our results showed that surfactant interacts with free radicals; surfactant reduced superoxide production by neutrophils and was peroxidized when incubated with resting and with stimulated cells. Vitamin E supplementation decreased superoxide radical production and in a dose-dependent manner decreased surfactant peroxidation. The decrease in lipid peroxidation by SOD was not significant. These findings suggest that phagocytes induce lipid peroxidation of lung surfactant, a reaction that might be prevented by antioxidants. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:17:07