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Titolo:
Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity: Experiences in a developingcountry
Autore:
da Costa, DE; Pai, MGK; Al Khusaiby, SM;
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 5, volume: 27, anno: 1999,
pagine: 312 - 317
SICI:
8755-6863(199905)27:5<312:CTOAAN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC SURFACTANT; BOVINE SURFACTANT; RANDOMIZED TRIAL; INFANTS; BIRTH; MORTALITY; THERAPY; LAMBS;
Keywords:
surfactant; randomized clinical trial; respiratory distress syndrome; newborn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: da Costa, DE POB 110,Postal Code 111, Seeb, Oman POB 110,Postal Code 111 Seeb Oman tal Code 111, Seeb, Oman
Citazione:
D.E. da Costa et al., "Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity: Experiences in a developingcountry", PEDIAT PULM, 27(5), 1999, pp. 312-317

Abstract

We conducted a randomized clinical trial to compare the effects of a synthetic (Exosurf(R)) and natural (Survanta(R)) surfactant in infants with neonatal respiratory distress syndrome. Eighty-nine patients were randomly allocated to receive one of the two surfactants. Primary outcome variables werethe acute and long-term effects of the surfactant preparations, i.e., ventilatory requirements at 24 h of age as judged by the oxygenation index (OI), and the combined incidence of chronic lung disease or death at 28 days. The Ols in the Exosurf(R) and Survanta(R) groups at 24 h were the same (10.1 and 7, respectively; P > 0.05). The magnitude and rapidity of response, however, were greater for Survanta(R) than for Exosurf(R). When arterial/alveolar oxygen tension ratios (a/A) were compared, the Exosurf(R) group had a significantly worse a/A ratio at 24 h than the Survanta(R) group (0.21 Exosurf(R) vs. 0.37 Survanta(R); P < 0.05). The long-term outcome as judged by the combined incidence of death or chronic lung disease was not differentin the two groups (18.6% Exosurf(R) vs. 15.2% Survanta(R); P > 0.05). Whenthe complications of prematurity were compared, there were no statistically significant differences between the two groups. We conclude that both preparations are reasonable choices for the treatment of respiratory distress syndrome of prematurity. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:45:54