Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pathology of synovitis and hemophilic arthropathy
Autore:
Roosendaal, G; van den Berg, HM; Lafeber, FPJG; Bijlsma, J;
Indirizzi:
Univrum,echt, Med Ctr, Van Creveld Clin, Innere Med Abt,Natl Hamphilie Zent Univ Utrecht Utrecht Netherlands NL-3508 GA Med Abt,Natl Hamphilie Zent
Titolo Testata:
ORTHOPADE
fascicolo: 4, volume: 28, anno: 1999,
pagine: 323 - 328
SICI:
0085-4530(199904)28:4<323:POSAHA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
GER
Soggetto:
EXPERIMENTAL HEMARTHROSIS; ARTICULAR-CARTILAGE; ARTHRITIS; RADICALS; DAMAGE; MODEL; IRON;
Keywords:
hemophilia; arthropathy; synovium; cartilage; blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Roosendaal, G Univrum,echt, Med Ctr, Van Creveld Clin, Innere Med Abt,NatlHamphilie Zent Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA Zent
Citazione:
G. Roosendaal et al., "Pathology of synovitis and hemophilic arthropathy", ORTHOPADE, 28(4), 1999, pp. 323-328

Abstract

Hemophilia is an X chromosome linked disease characterized by an increasedtendency to hemorrhage. Due to recurrent haemarthroses specific changes occur in synovium and cartilage. This process is called haemophilic arthropathy. The pathogenetic mechanisms involved are not precisely known. Current concepts, which are based on experimental in vitro studies and clinical experience, hold that the synovium becomes catabolically active because of the exposure to blood components and as a result induces cartilage destruction. A considerable amount of reports concerning blood induced joint damage suggest that synovial changes have a leading role in the development of the joint damage and therefore precede the changes in cartilage. However, there are also observations that question whether this is the only and the initiating mechanism of joint damage in hemophilia they hold that intraarticular blood has a direct harmful effect on cartilage before synovial changes and suggest that joint damage may occur before synovial inflammation is evident. Primarily there may be damage of articular cartilage with synovitis as a consequence. These studies show that synovitis is involved, but that it is not the onlymechanism in the joint damage caused by intra-articular bleeding. These findings do not contradict the current concept of blood-induced cartilage damage in which synovial changes are thought to play an important role. Several pathological processes are possibly involved, some of them occuring in parallel and others sequentially. Possibly intra-articular blood first has andirect effect on cartilage, and then it affects the synovium. Thus, both processes occur in parallel, and while they influence each other they probably do not depend on each other. This concept resembles degenerative joint damage as found in osteoarthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:16:58