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Titolo:
Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamus
Autore:
Reuss, S; Hermes, B; Fuchs, E; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Anat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Mainz, Dept Anat, D-6500 Mainz, Germany Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 nz, Dept Psychiat, D-6500 Mainz, Germany German Primate Ctr, Div Neurobiol, Gottingen, Germany German Primate Ctr Gottingen Germany Div Neurobiol, Gottingen, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 266, anno: 1999,
pagine: 29 - 32
SICI:
0304-3940(19990430)266:1<29:DANCOM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE TURNOVER RATES; OVARIECTOMIZED RATS; GONADOTROPIN-SECRETION; LUTEINIZING-HORMONE; PROLACTIN; ESTRADIOL; NUCLEUS; BRAIN; PROGESTERONE; RELEASE;
Keywords:
medial preoptic area; hypothalamus; rat; monoamines; sex difference; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Reuss, S Univ Mainz, Dept Anat, Saarstr 19-21, D-6500 Mainz, Germany Univ Mainz Saarstr 19-21 Mainz Germany D-6500 500 Mainz, Germany
Citazione:
S. Reuss et al., "Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamus", NEUROSCI L, 266(1), 1999, pp. 29-32

Abstract

The present study was conducted to investigate whether monoamines and their metabolites in the medial preoptic area (mPOA) of the rat hypothalamus exhibit differences in their contents between day and night. We therefore sampled the mPOA from adult animals of either sex at the middle of the light or dark period, respectively, and analyzed the tissue by means of high performance liquid chromatography with electrochemical detection. We found that,in female animals at mid-night, dopamine and 3,4-dihydroxyphenyl acetic acid (DOPAC) was reduced to 43 and 30%, respectively, of daytime levels, while the norepinephrine content was doubled. No significant differences were observed in male animals. We also conducted immunohistochemistry of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), in sections from perfusion-fixed male rats and showed that TH is present in neuronal perikarya and processes in the anteroventral periventricular region of the mPOA, while DBH was only seen in fibers and terminals. Our results of sex-specific and day time-dependent variations in dopamine and norepinephrine concentrations indicate that the two monoaminesare candidate neurotransmitters that may transmit diurnal information to the mPOA, (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:24:08