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Titolo:
Cerebral blood flow threshold and regional heterogeneity of heat shock protein 72 induction following transient forebrain ischemia in rats
Autore:
Goda, H; Yao, H; Nakane, H; Fukuda, K; Nakahara, T; Ibayashi, S; Uchimura, H; Fujishima, M;
Indirizzi:
Kyushuanniv, Fac Med, Dept Internal Med 2, Higashi Ku, Fukuoka 8128582, Jap Kyushu Univ Fukuoka Japan 8128582 ed 2, Higashi Ku, Fukuoka 8128582, Jap Hizen Natl Mental Hosp, Ctr Emot & Behav Disorders, Saga 8420104, Japan Hizen Natl Mental Hosp Saga Japan 8420104 Disorders, Saga 8420104, Japan Kyushu Univ, Fac Sci, Dept Chem, Higashi Ku, Fukuoka 8128581, Japan KyushuUniv Fukuoka Japan 8128581 em, Higashi Ku, Fukuoka 8128581, Japan
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 5, volume: 24, anno: 1999,
pagine: 679 - 683
SICI:
0364-3190(199905)24:5<679:CBFTAR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; GLUCOSE-UTILIZATION; TEMPORAL PROFILE; MESSENGER-RNA; GERBIL BRAIN; DEATH; LOCALIZATION; EXPRESSION; DOPAMINE; RELEASE;
Keywords:
hippocampus; striatum; spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Goda, H Kyushuokaiv, Fac Med, Dept Internal Med 2, Higashi Ku, Maidashi 3-1-1, Fuku Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 8128582 ashi 3-1-1, Fuku
Citazione:
H. Goda et al., "Cerebral blood flow threshold and regional heterogeneity of heat shock protein 72 induction following transient forebrain ischemia in rats", NEUROCHEM R, 24(5), 1999, pp. 679-683

Abstract

Heat shock proteins (HSPs) induced by brain ischemia may play an importantrole in neuroprotection from neuronal degeneration. In this study, we examined the cerebral blood flow (CBF) threshold to produce regional differences in HSP72 induction after transient forebrain ischemia in spontaneously hypertensive rats (SHRs). Female SHRs were subjected to 20 min of cerebral ischemia induced by bilateral carotid artery occlusion. The CBF was measured by laser Doppler flowmetry. At forty-eight hours after cerebral ischemia and reperfusion, the rats were decapitated and the brains were removed. Specific areas (hippocampal CA1, CA2-3, dentate gyrus, dorsolateral and ventromedial striatum, and parietal cortex) were thereafter dissected from the brain. The amounts of HSP72 in these samples were determined using Western blotanalysis. In the hippocampus, HSP72 was induced when the CBF decreased to less than 18-25% of the resting level. The mean values of HSP72 produced inthe CA1 area, CA2-3 area, and the dentate gyrus following ischemia and reperfusion treatment were 4.44 +/- 1.43 (+/-SD) ng/mu g prtein, 3.51 +/- 0.72ng/mu g protein and 3.77 +/- 1.05 ng/mu g protein, respectively. In the parietal cortex, the amount of HSP72 induction was less pronounced (2.55 +/- 0.40 ng/mu g protein), while HSP72 was hardly detected at all in the striatum, even under conditions of very severe CBF reduction and reperfusion, We demonstrated the existence of both a CBF threshold (i.e., approximately 20%of the resting level) for HSP72 induction and regional heterogeneity for the induction of HSP72 protein.

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Documento generato il 30/03/20 alle ore 18:33:58