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Titolo:
Tubulin and glial fibrillary acidic protein gene expression in developing fetal human brain at midgestation
Autore:
Pal, U; Chaudhury, S; Sarkar, PK;
Indirizzi:
Indian Inst Chem Biol, Div Neurobiol, Calcutta 700032, W Bengal, India Indian Inst Chem Biol Calcutta W Bengal India 700032 032, W Bengal, India
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 5, volume: 24, anno: 1999,
pagine: 637 - 641
SICI:
0364-3190(199905)24:5<637:TAGFAP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING RAT-BRAIN; THYROID-HORMONE; MESSENGER-RNA; ACTIN; CYTOSKELETAL; 2ND-TRIMESTER; ASTROCYTES; GESTATION; ISOTYPES; MOUSE;
Keywords:
tubulin; glial fibrillary acidic protein; gene expression; human fetal brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sarkar, PK Indian,Inst Chem Biol, Div Neurobiol, 4 Raja SC Mullick Rd, Calcutta 700032 Indian Inst Chem Biol 4 Raja SC Mullick Rd Calcutta W Bengal India 700032
Citazione:
U. Pal et al., "Tubulin and glial fibrillary acidic protein gene expression in developing fetal human brain at midgestation", NEUROCHEM R, 24(5), 1999, pp. 637-641

Abstract

Developmental alterations in the expression of glial fibrillary acidic protein (GFAP) and alpha-tubulin were examined at the level of mRNA and protein in human fetal brain between weeks 13-23 of gestation. Except for a transient increase at week 15, GFAP expression in the cytoskeletal (CSK) fraction was low until week 17, when it increased steadily to week 23, corresponding to the phase of glial proliferation. The developmental profile of alpha-tubulin in the CSK fraction displayed a biphasic pattern, with an initial rise between weeks 13-16 coinciding with the early phase of neuroblast multiplication, and a second rise between weeks 17-23 corresponding to the phaseof glial proliferation. No significant difference in the spatial distribution of alpha-tubulin was found in different region of brain but GFAP expression varied with a higher level in cerebellum than that in cerebrum at latemidgestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:59:46