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Titolo:
Case report of basaloid squamous cell carcinoma of the oropharynx: Clinical and histopathologic characteristics of an aggressive tumor entity.
Autore:
Rickert, D; Engelke, JC; Tietze, L; Westhofen, M;
Indirizzi:
Rhein Westfal TH Aachen, Klin Hals Nasen Ohrenheilkunde Plast Kopf & Halsc, Rhein Westfal TH Aachen Aachen Germany D-52074 kunde Plast Kopf & Halsc,
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 4, volume: 78, anno: 1999,
pagine: 189 - 193
SICI:
0935-8943(199904)78:4<189:CROBSC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
GER
Soggetto:
ADENOID CYSTIC CARCINOMA; UPPER AERODIGESTIVE TRACT; HEAD; NECK; HYPOPHARYNX; ESOPHAGUS; FLOOR; MOUTH;
Keywords:
head and neck cancer; basaloid squamous cell carcinoma; differential diagnosis; prognosis; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rickert, D Rhein Westfal TH Aachen, Klin Hals Nasen Ohrenheilkunde Plast Kopf & Halsc, Rhein Westfal TH Aachen Pauwelsstr 30 Aachen Germany D-52074 ,
Citazione:
D. Rickert et al., "Case report of basaloid squamous cell carcinoma of the oropharynx: Clinical and histopathologic characteristics of an aggressive tumor entity.", LARY RH OTO, 78(4), 1999, pp. 189-193

Abstract

Background: Basaloid squamous cell carcinoma is a variant of squamous cellcarcinoma which is located predominantly in the upper aerodigestive tract. The cardinal histopathologic feature is a biphasic cellular pattern of basaloid and squamous components in a close relationship. Major differential diagnoses include adenoid cystic, adeno, squamous, adenosquamous, and basal cell carcinomas. This entity may commonly pose diagnostic difficulties, especially on small biopsy material, if only the basaloid component of the tumor is included. Case report: A tumor of the oropharynx (T2) was detected ina 61-year-old man. After endoscopic biopsy, this tumor was histologically identified as an adenocarcinoma. A very rapid tumor growth became obvious during the patients' staging. After pharyngectomy and neck dissection, the histopathological diagnosis was corrected to a basaloid squamous cell carcinoma. The definite diagnosis was not made on biopsy material, because only the basaloid component of the tumor was included. Discussion: Basaloid squamous carcinoma is a biologically aggressive tumor with high proliferative activity and a propensity to destructive local growth and early regional and distant metastasis. Literature predominantly indicates that basaloid squamous cell carcinoma is an aggressive variant of squamous cell carcinoma and is prognostically worse than the regular squamous cell carcinoma. Conclusion: Because of the aggressive biological behavior of basaloid squamous cell carcinoma, radical surgery combined with radiation and chemotherapy is the treatment of choice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:14:46