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Titolo:
Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch belted rabbits
Autore:
Marini, RP; Li, XT; Harpster, NK; Dangler, C;
Indirizzi:
MIT, Div Comparat Med, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Div Comparat Med, Cambridge, MA 02139 USA Univ Chicago, Anim Resources Ctr, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 im Resources Ctr, Chicago, IL 60637 USA Angell Mem Hosp, Boston, MA USA Angell Mem Hosp Boston MA USAAngell Mem Hosp, Boston, MA USA
Titolo Testata:
LABORATORY ANIMAL SCIENCE
fascicolo: 2, volume: 49, anno: 1999,
pagine: 153 - 160
SICI:
0023-6764(199904)49:2<153:CPPAWK>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; INDUCED PULMONARY-EDEMA; INDUCED CARDIOMYOPATHY; KETAMINE-XYLAZINE; CATECHOLAMINE CARDIOMYOPATHY; CASSIA-OCCIDENTALIS; POISONED RABBITS; BLOOD-PRESSURE; VITAMIN-E; COMBINATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Marini, RP MIT, Div Comparat Med, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 mparat Med, Cambridge, MA 02139 USA
Citazione:
R.P. Marini et al., "Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch belted rabbits", LAB ANIM SC, 49(2), 1999, pp. 153-160

Abstract

Background and Purpose: After myocardial necrosis and fibrosis was observed in five rabbits which had been anesthetized a variable number of times, the potential relationship of these lesions and anesthesia was evaluated in 35 other rabbits. Methods: Anesthesia was induced by intramuscular administration of ketamine and xylazine followed by infusion of lactated Ringer's solution also containing ketamine and xylazine, Group A rabbits (n = 9) were subjected to multiple anesthesias and were evaluated by echocardiography, thoracic radiography, electrocardiography, determination of serum coronavirus titer, vitaminE concentration, and complete necropsy. Prior to a single acute procedure followed by necropsy, group B rabbits (n = 11) were evaluated by echocardiography only. Group C rabbits (n = 10) had never been anesthetized and were necropsied after euthanasia, Group D rabbits (n = 5) had intermediate anesthesia exposure history and were evaluated by echocardiography only. Myocardial fibrosis was scored semi-quantitatively on a scale of 0 to 4. Results: Canine coronavirus test results were negative; hypovitaminosis E was evident, and fibrosis scores were significantly increased in group A, compared with group B or group C, rabbits. Conclusion: Etiologic differentials included alpha(2)-agonist-mediated coronary vasoconstriction with associated myocardial hypoperfusion, hypovitaminosis E and free radical injury, and other anesthetic-induced physiologic trespass.

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Documento generato il 12/07/20 alle ore 05:47:43