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Titolo:
Identification of receptor ligands with phage display peptide libraries
Autore:
Koivunen, E; Arap, W; Rajotte, D; Lahdenranta, J; Pasqualini, R;
Indirizzi:
Burnham Inst, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037Burnham Inst, La Jolla, CA 92037 USA Univ Helsinki, Dept Biosci, Div Biochem, Viikinkaari, Finland Univ Helsinki Viikinkaari Finland ci, Div Biochem, Viikinkaari, Finland
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 40, anno: 1999,
pagine: 883 - 888
SICI:
0161-5505(199905)40:5<883:IORLWP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PEPTIDES; INTEGRIN ALPHA(V)BETA(3); FILAMENTOUS PHAGE; IN-VIVO; EPITOPE LIBRARY; SELECTION; DOMAIN; ANGIOGENESIS; RGD; ANTAGONISTS;
Keywords:
phage display; peptide libraries; integrins; targeting; biopanning; receptors; ligands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Pasqualini, R Burnham Inst, 10901 N Torrey Pines Rd, La Jolla, CA 92037 USA Burnham Inst 10901 N Torrey Pines Rd La Jolla CA USA 92037 A
Citazione:
E. Koivunen et al., "Identification of receptor ligands with phage display peptide libraries", J NUCL MED, 40(5), 1999, pp. 883-888

Abstract

With the development and maturation of the technology of displaying peptides on bacteriophage, it has become possible to isolate peptide ligands to various targets. In the phage display strategy, up to 10(9) peptides of different permutations are expressed on the surface of filamentous phage. Thus,peptides capable of binding target molecules in vitro and even target tissues in vivo can be identified. In recent years, a series of libraries that display degenerate peptides of different lengths have been constructed, andspecific ligands to cell surface receptors, such as integrins, have been isolated. In the in vivo biopanning, peptides targeting distinct organs or tumors have been rescued after intravenous administration of phage librariesinto mice. In one application, the isolated peptide ligands have been usedto direct a cytotoxic drug to tumor vasculature in mice. Further applications in radioimaging and radiotherapy are being investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:06:07